1*Department of Pharmacognosy, Faculty in RR College of Pharmacy, Bengaluru, Karnataka. Email: seema.gupta@rrcollegeofpharmacy.com (Corresponding Author)
2Department of Pharmacology, Faculty in MVM College of Pharmacy, Bengaluru, Karnataka. Email: drx.ushaverma@gmail.com
3Department of Pharmacy Practice, Student in Mallige College of Pharmacy, Bengaluru, Karnataka. Email: priyatk5055@gmail.com
Objective: The study was mainly designed to evaluate the antioxidant properties of Punica granatum dried leaf extract. Experimental plants extract phytochemical screening was done and has shown the presence of pyrogallol in the leaf and exhibited potential in vitro antioxidant property.
Methods: The cardioprotective and hepatoprotective role of the plant was investigated by measuring level of serum and, cardiac enzymes with drug induced stressed animals. On observation the levels of AST, ALT, LDH and CK tends to be normal in Punica granatum dried leaf extract treated animals rather than non-treated animals, where both animal groups were induced toxicities with doxorubicin and Isoproterenol.
Results: Further, Macro and histopathological studies suggested the conservation of healthy cardiac architecture.
Conclusion: Thus, we have concluded that Punica granatum dried leaf extract also could be a new addition as cost effective herbal antioxidant.
Key word: Doxorubicin, Isoproterenol, cardiotoxicity, hepatotoxicity and herbal antioxidant
How to cite this article: Gupta S, Verma U, Priya TK. Advanced GC–MS Characterization of Bioactive Constituents in Punica granatum Leaves and Their Therapeutic Antioxidant Potential Against Cardiac and Hepatic Toxicity in Rats. Int J Drug Deliv Technol. 2026;16(13s): 312-319. DOI: 10.25258/ijddt.16.13s.34
Source of support: Nil.
Conflict of interest: None