1Professor and Head, Department of Pharmaceutics, Santhiram College of Pharmacy, Nandyal-518501, Andhra Pradesh, India.
2*Professor and Head, Department of Pharmacy Practice, Santhiram College of Pharmacy, Nandyal-518501, Andhra Pradesh, India. E-Mail id: reugandar@gmail.com. https://orcid.org/0000-0002-7014-0864 (Corresponding Author)
3,4Research Scholars, Department of Pharmaceutics, Santhiram College of Pharmacy, Nandyal-518501, Andhra Pradesh, India.
Background: The commonly used hypolipidemic agent, fenofibrate has low aqueous solubility and limited dissolution-based absorption leading to random oral bioavailability. To overcome these limitations, the present study attempted to design and test a super saturable self-emulsifying drug delivery system (SS-SEDDS) that increased the level of solubility and maintained a supersaturated state.
Methods: Solubility screening was done to identify the right oils and surfactants in addition to co-surfactants, and pseudo-ternary phase diagrams were then constructed in order to determine the effective self-emulsifying regions. Recipes were designed to make use of hydroxypropyl methylcellulose as an anti-precipitation agent to maintain the oversaturation.
Results: The optimized equation exhibited fast self-emulsification, nanoscale level of droplets at a narrow distribution and a good zeta potential, which indicate the physical stability. Investigations into super saturation showed long-term staying above the equilibrium solubility of a drug, which proves successful inhibition of precipitation. Dissolution tests in murdering revealed that ravage promote drug circulation relative to pure fenofibrate and customary formulations. The improved performance is credited to both the presence of better solubilization, smaller droplet size and continued supersaturation.
Conclusion: On the whole, the results suggest that SS-SEDDS is a strong and effective platform to enhance the dissolution behaviour and potential oral bioavailability of fenofibrate, and that it is applicable in the other poorly water-soluble drugs.
KEYWORDS: Fenofibrate; SS-SEDDS; Supersaturation; Self-emulsifying drug delivery system; Solubility enhancement; Dissolution improvement; Lipid-based formulation; Precipitation inhibition; Oral bioavailability
How to cite this article: Badarinath AV, Ugandar RE, Obaiah P, Rao SS. Super Saturable Self-Emulsifying Drug Delivery System of Fenofibrate: Formulation Optimization and Evaluation for Improved Oral Bioavailability. Int J Drug Deliv Technol. 2026;16(13s): 530-537. DOI: 10.25258/ijddt.16.13s.57
Source of support: Nil.
Conflict of interest: None