1PhD Scholar (Public Health), Noida International University, India.
2Assistant Professor (Public Health), Noida International University, India.
Background: Currently, the most common monogenetic diseases globally are inherited disorders of haemoglobin (Hb). Thalassemia, which is resulted by mutations affecting Hb's globin chain subunits, is the most common inherited disorder. Thalassemia Major, which is also called Cooley's anaemia, is the severe type. As TM's prevalence varies extensively across diverse regions as well as populations, it signifies a key global health burden.
Objective: TM in India is the prevalent genetic disorder, as specified by the national statistics report. Therefore, it requires frequent Blood Transfusions (BT) due to severe anaemia. This regular BT affects the Quality of Life (QoL) due to the Iron Overload (IO) in the transfusion received patients. This results in decreased QoL in the patients. Therefore, this review focuses on the impacts of QoL in blood-transfused TM patients in India. Besides, this review explores the risks and burdens related to the QoL in blood-transfused TM patients.
Conclusion: The QoL in the TM affected patients could be increased by exploring the clinical trials and case studies. This contributes to public health by highlighting the gap between regular BTs.
Keywords: Thalassemia major, Quality of Life, Blood transfusion, Transfusion Dependent Thalassemia, Beta Thalassemia, iron overload, economic burden, and social burden.
How to cite this article: Sharma S, Lenka AK. Impact of Quality of Life on Blood Transfusion in Thalassemia Major Patients in India: A Review. Int J Drug Deliv Technol. 2026;16(13s): 530-538. DOI: 10.25258/ijddt.16.13s.58
Source of support: Nil.
Conflict of interest: None