1Assistant Professor, Department of Sangyaharan, Faculty of Ayurveda, Institute of Medical Science, Banaras Hindu University, Varanasi, 221005. E-mail: rkj41a@bhu.ac.in. ORCID ID: 0000-0001-7856-9633
2Ph.D. Research Scholar, Department of Sangyaharan, Institute of Medical Science, Banaras Hindu University, Varanasi, 221005. E-mail: mohitkumar.dsvv@gmail.com. ORCID ID: 0009-0003-2244-6986
3Ph.D. in Yogic Science and Naturopathy, Department of Sangyaharan, Institute of Medical Science, Banaras Hindu University, Varanasi, 221005. E-mail: vix09x@gmail.com
4*Ph.D. Research Scholar, Department of Sangyaharan, Institute of Medical Science, Banaras Hindu University, Varanasi, 221005. E-mail: n669599@gmail.com. Mobile: 7309601587. ORCID ID: 0009-0006-7779-3725 (Corresponding author)
5Ph.D. in Yoga, Department of Sangyaharan, Institute of Medical Science, Banaras Hindu University, Varanasi, 221005. E-mail: sita.kumari10@bhu.ac.in
6Ph.D. Research Scholar, Department of Sangyaharan, Institute of Medical Science, Banaras Hindu University, Varanasi, 221005. E-mail: deelipkumarsingh621@gmail.com
7Professor, Department of Biochemistry, Faculty of Modern Medicine, IMS, BHU, India. E-mail: drsurendram2@gmail.com
Background: This study aimed to find out an alternative method e.g. Agnikarma, and some herbal medicine by which pain can be relieved without any side effect but there was no any scientific study on biochemical level yet so for present research work total 40 adult patients of both sex with narrow age, weight and height were selected and divided randomly in two groups containing 20 patients each. Group 1 was given Yograj Guggulu 1000 mg in the morning and evening and follow up- weekly for three weeks. In Group 2 Agnikarma therapy was done weekly for three weeks.
Methods: The evaluation of β-endorphin, Substance-P & Dopamine in patient serum before treatment & after three weeks i.e. at completion of study were done. Prior to registration of patient for the proposed study, well informed consent of patients were taken after proper ethical approval from our institute. The observation made on response of both groups, were recorded on a standard proforma. The comparison of both the groups was calculated statistically.
Results: Substance-P is a pain mediator & it is decreased after treatment in our study & dopamine increases in our study while there is no significant effect on β-endorphin.
Conclusion: There are no conflict of interest for this study and we have ethical approval by Institute Ethical Committee (EC Registration no. ECR/526/Inst/UP/2014 Dt. 31.1.14): Dean/2015-16/EC/78.
Key word- Agnikarma, Yograj Guggulu, β-endorphin, Substance-P & Dopamine.
How to cite this article: Jaiswal RK, Kumar M, Jaiswal V, Neha, Kumari S, Kumar D, Mishra SP. Role of Ayurvedic Herbo-Mineral Formulation Yograj Guggulu and Agnikarma (Traditional Cautery) in Osteoarthritis of Knee Joint Pain and Their Effects on Blood Levels of Dopamine, Substance-P and β-Endorphins: An Open-Label, Non-Controlled Comparative Randomised Clinical Trial. Int J Drug Deliv Technol. 2026;16(13s): 610-615. DOI: 10.25258/ijddt.16.13s.67
Source of support: Nil.
Conflict of interest: None