1*MATS School of Sciences (Chemistry), MATS University, Pandri Campus, Raipur, Chhattisgarh 492009, India
*Corresponding Author: Prashant Mundeja. Email Address: prashantmundeja@gmail.com
Background: Surfactants have shown promise in pharmaceutics addressing stability, toxicity, and drug solubility issues. However, developing effective medication delivery mechanisms is crucial. Our current study focuses on understanding the micellization behavior of Triton X-100, a surface-active ionic liquid (SAIL) in the presence of anti-inflammatory drug (NSAIDs). The study employs surface tension measurements to assess the micellization nature of the surfactant and drug mixture at various concentrations. Viscosity properties of the mixed system are followed by viscosity techniques.
Methods: Interaction between anionic surfactants and drugs. The results show a significant change in the CMC value with the rise in drug concentration, which depends on the nature of the drug. Triton X-100 (TX-100), a non-ionic surfactant, has been interacted with Ibuprofen drug characterized by ¹H NMR and FTIR spectroscopic techniques in the solid state. These artificially produced surfactants are effective in raising the solubility and bioavailability of drug molecules. Additional screening was done on surfactants to check for antibacterial and antifungal properties.
Keywords: Surfactants, Drug (NSAIDs), and Micellization
How to cite this article: Khuntia R, Mundeja P. Influence of Micellization Behaviour of Non-Ionic Surfactant with Anti-Inflammatory Drug. Int J Drug Deliv Technol. 2026;16(13s): 718-727. DOI: 10.25258/ijddt.16.13s.77.
Source of support: Nil.
Conflict of interest: None