1Assistant Professor at Jai Narayan College of Paramedical, Bhopal, JNCT Professional University Bhopal, MP. Email: Hemantjha112211@gmail.com
2Assistant Professor at Jai Narayan College of Paramedical, Bhopal, JNCT Professional University Bhopal, MP. Email: pmmewada1997@gmail.com
3Assistant Professor at Jai Narayan College of Paramedical Bhopal, JNCT Professional University Bhopal, MP. Email: jayantitiwary6@gmail.com
4Assistant Professor at Jai Narayan College of Paramedical Bhopal, JNCT Professional University Bhopal MP. Email: aakankshapawar2022@gmail.com
5Assistant Professor at Jai Narayan College of Paramedical Bhopal, JNCT Professional University Bhopal MP. Email: anandakhilesh07@gmail.com
6Principal at Jai Narayan College of Paramedical Bhopal, JNCT Professional University Bhopal MP. Email: manishshrivastava259@gmail.com
7Junior Physiotherapist at RK Physiotherapy & Neuro Solution Kohe Fiza. Email: Surendramewada088@gmail.com
Background: Atherosclerosis is a major cause of cardiovascular morbidity and mortality. Serum cholesterol binding reserve (SCBR) reflects the capacity of serum lipoproteins to solubilize additional cholesterol and is considered an indirect marker of reverse cholesterol transport. Reduced SCBR has been linked to increased atherogenic risk.
Objective: To estimate serum cholesterol and SCBR in patients with essential hypertension and to compare the findings with healthy age- and sex-matched controls.
Materials and Methodology: The study included 50 patients with essential hypertension and 25 healthy controls. Fasting serum cholesterol was measured by an enzymatic method. SCBR was assessed by incubating serum with crystalline cholesterol and determining the increase in cholesterol concentration after incubation. Statistical analysis was performed to compare mean values between groups and to assess correlations.
Results: Mean serum cholesterol levels were significantly higher in hypertensive patients (208.88 ± 37.71 mg/dL) than in controls (186.80 ± 32.01 mg/dL) (p < 0.05). Mean SCBR was markedly lower in hypertensive patients (24.50 ± 6.24 mg/dL) compared to controls (59.72 ± 6.99 mg/dL) (p < 0.001). A strong negative correlation was observed between serum cholesterol and SCBR in hypertensive patients (r = –0.876), whereas a positive correlation was noted in controls (r = +0.706).
Conclusion: Patients with essential hypertension exhibit significantly reduced SCBR despite only modest elevations in serum cholesterol. Reduced SCBR may contribute to accelerated atherogenesis in hypertension and may serve as a better biochemical marker of atherogenic risk than serum cholesterol alone.
Keywords: Essential hypertension; Serum cholesterol; Serum cholesterol binding reserve; Reverse cholesterol transport; Atherosclerosis.
How to cite this article: Jha H, Mewada P, Kumari J, Pawar A, Anand A, Shrivastava M, Mewada S, Estimation Of Serum Cholesterol Binding Reserve In Patients With Essential Hypertension..Int J Drug Deliv Technol. 2026;16 (13s): 68-71; DOI: 10.25258/ijddt.16.13s.8
Source of support: None
Conflict of interest: None