1*PhD Scholar, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India, Pin - 416416. Email: kulkarnikiran986@gmail.com (Corresponding Author)
2Professor & HOD, Dept. of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India, Pin - 416416
The present investigation deals with cytotoxic investigation of Balanites aegyptiaca (L.) Del. Leaves by using MTT assay technique. Different extracts have been assessed against Human breast cancer cell line (MCF-7) and Normal cell line (HBL-100). The ethanolic extract shows potent cytotoxity against MCF-7 cell line. The efficacy of ethanolic extract against normal cell line have been confirmed through high IC50 and low percent inhibition. An apoptosis study was conducted on potent ethanolic extract against the MCF-7 cell line by using flow cytometry. Ethanolic extract showed late apoptosis & confirmed cell cycle arrest at the Sub G0 phase. So ethanolic extract demonstrated potential to evacuate apoptosis on Human breast cancer cell line (MCF-7) and confirmed anticancer activity.
Keywords: Balanites aegyptiaca (L.) Del. Leave, Human breast cancer cell line (MCF-7), Normal cell line (HBL-100), apoptosis study
How to cite this article: Kulkarni KM, Kondawar MS. The Comparative Cytotoxic Investigation of Balanites Aegyptiaca (L.) Del Against Human Breast Cancer Cell Line (MCF-7) and Normal Cell Line (HBL-100) Through Apoptotic Pathway by Using Flow Cytometry Analysis. Int J Drug Deliv Technol. 2026;16(14s): 480. DOI: 10.25258/ijddt.16.14s.49
Source of support: Nil.
Conflict of interest: None