1Department of Biotechnology, RVS College of Arts and Science, Sulur, Coimbatore, Tamil Nadu, India.
2Department of Plant Biology & Plant Biotechnology, Women's Christian College, Chennai-600 006, Tamil Nadu, India.
3Department of Chemistry, Dravidian University, Kuppam-517 426, Chittoor (DT), Andhra Pradesh, India.
4School of Sciences, Bharata Mata College (Autonomous), Thrikkakara, Kochi-682 021, Kerala, India.
Aegle marmelos, commonly known as bael, is a medicinal plant widely recognized for its therapeutic properties. The leaf extract of A. marmelos has garnered significant attention in contemporary research due to its rich phytochemical composition and diverse biological activities. This research will investigate the phytochemical constituents of A. marmelos leaf extract, including alkaloids, flavonoids, phenolic compounds, and terpenoids, among others, which contribute to its pharmacological potential. The mechanisms underlying these activities are investigated, providing insights into the molecular pathways through which the leaf extract of A. marmelos exerts its beneficial effects. The leaf extract was obtained using methanol and water as solvents. Total phenol content, DPPH, FRAP, SOD, and total antioxidant activity were assessed using the phosphomolybdenum method. Compound identification was conducted using a UV-visible spectrophotometer, FTIR, TLC, and GCMS. The findings demonstrate that the leaf extract possesses antimicrobial and antioxidant potential. Molecular docking studies with PPARγ proteins further confirmed these findings, suggesting that these leaves may be useful in the treatment of microbial infections, anti-inflammatory responses, and metabolic disorders, including cancer. Our findings demonstrated the leaf extract was promising in medicinal applications due to its antimicrobial, antioxidant properties and wide applicability in the treatment of pathogenic infections and anti-inflammatory responses and metabolic disorders, including diabetes and cancer.
Keywords: A. marmelos, Antioxidant, GCMS, Molecular Docking, PPARγ Proteins.
How to cite this article: Kumaran P, Udhayakumar M, Jeyasundar PGSA, Manokaran S, Palanivelu M, David SJ, Bhagya PM, Krishna TPA, Parameswaran ADM. Bioactive Compounds in Aegle marmelos Leaf Extract: GC-MS Analysis, Antioxidant, and Antimicrobial Properties with in silico Insights into PPARγ Interactions. Int J Drug Deliv Technol. 2026;16(15s): 913-925. DOI: 10.25258/ijddt.16.15s.102
Source of support: Nil.
Conflict of interest: None