1Department of Biochemistry, Government Medical College and Cancer Hospital, Chhatrapati Sambhajinagar. Email: bhagwatkale2644@gmail.com
2D.Y. Patil Institute of Allied Health Sciences, Pune
3,4Department of Biochemistry, B.J. Government Medical College and Sassoon General Hospital, Pune
5Department of Biochemistry, Government SNK Medical College and research Centre, Kopergaon, Ahilyanagar
6Department of Biochemistry, Government Medical College and Hospital, Alibag
Background: CEA and CA 19.9 are most common markers used in clinical practice in management of PDAC. Preoperative serum CA19-9 and CEA level are closely related with survival time in PC patients and therefore may be used for evaluating the prognosis for PDAC. Now, the question posed in this study was whether the pancreatic enzymes lipase and amylase add significance towards increasing diagnostic and prognostic efficacy of PDAC furthermore. Thus, this study is planned to explore whether measured amylase and lipase can lead to statistically significant improvement in the diagnostic and prognostic efficacy of PDAC.
Methods: The study includes 50 clinically diagnosed and confirmed cases of PDAC. 50 age and sex matched healthy volunteers were selected and used for comparison of result. ROC analysis of CA-19.9 and CEA was the major statistical analysis to find cut-off. Sensitivity, specificity, accuracy, PPV and NPV of CEA, CA19.9, amylase and lipase were calculated in PDAC to know their diagnostic efficacy.
Results: Increased serum lipase and amylase with increased LAR indicates pancreatic duct blockage while decreased serum lipase and serum amylase with increased LAR may hint for pancreatic insufficiency.
Conclusions: Preoperative amylase and lipase levels and the calculation of the LAR at the time of localized pancreatic cancer diagnosis might be helpful in the risk assessment in surgically resectable pancreatic cancer.
Keywords: Carcinoembryonic antigen, Carbohydrate Antigen 19–9, Pancreatic Ductal Adenocarcinoma, Amylase, Lipase etc.
How to cite this article: Kale B, Girish S, Waghmode A, Salgar S, Gaikwad S, Yadav B. Evaluation of Diagnostic Performance of Amylase and Lipase in Pre-Operative Pancreatic Ductal Adenocarcinoma. Int J Drug Deliv Technol. 2026;16(15s): 26-31. DOI: 10.25258/ijddt.16.15s.4
Source of support: Nil.
Conflict of interest: None