International Journal of Drug Delivery Technology
Volume 16, Issue 15s, 2026

TARGETING AGING MECHANISMS: PHARMACOKINETIC AND ADMET CHALLENGES IN SENESCENT PHYSIOLOGY

Sonali K. Diwate1,2, Suresh G. Killedar3, Deepak Sawant2, Rushikesh Kumbhar2, Vaishnavi Hiremath4, Vaishnavi Koulge5, Anuja More2, Abhinandan R Patil2*

1Department of Pharmaceutics, Research Centre at Tatyasaheb College of Pharmacy, Tatyasaheb Kore Vidyanagari, Kolhapur, Maharashtra, India. 416113.

2D.Y. Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, INDIA.

3Anandi Pharmacy College, A/P Kalambe, Tarf Kale, Kolhapur, Maharashtra, India. 416205

4Department of Quality Assurance Techniques, Bharati Vidyapeeth (Deemed to be University) (BVDU), Poona College of Pharmacy, Pune, India.

5Ashokrao Mane College of Pharmacy, Peth Vadgoan, Maharashtra, India.

* Corresponding Author: Abhinandan R. Patil, Department of Pharmaceutics, D.Y. Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, INDIA. Email: abhisirdyp@gmail.com

ABSTRACT

Natural bioactive agents include flavonoids, mitochondrial-targeted antioxidants, and NAD+ precursors are under growing investigation as well as synthetic agents like dasatinib and rapamycin as promising senotherapeutics due to their ability to control these hallmarks. This broad overview incorporates the mechanistic understanding of the action of both plant-derived and synthetic agents on major aging processes and, in particular, the pharmacodynamics and pharmacokinetics of their actions in aging (or senescence) physiology. The changes in the performance of the CYP450 enzymes, tissue distributions, renal and hepatic clearance as well as gut microbiome composition with age significantly alter the ADMET profile of these agents, which affects the efficacy and safety of these agents. We critically review translational barriers, uncover gaps in age-relevant preclinical models, and suggest strategic solutions on how best to streamline senotherapeutic dosing and delivery system. Through a synthesis of the views of pharmacognosy, molecular geroscience, and translational pharmacology, this synthesis offers a holistic approach to safe and effective interventions that can lengthen healthspan in aging people.

Keywords: Hallmark of aging, Pharmacognosy, Quercetin, ADMET challenges, Senolytics, mTOR inhibitors, NAD+ precursors, Geroprotectors.

How to cite this article: Diwate SK, Killedar SG, Sawant D, Kumbhar R, Hiremath V, Koulge V, More A, Patil AR. TARGETING AGING MECHANISMS: PHARMACOKINETIC AND ADMET CHALLENGES IN SENESCENT PHYSIOLOGY. Int J Drug Deliv Technol. 2026;16(15s): 392-397. DOI: 10.25258/ijddt.16.15s.46

Source of support: Nil.

Conflict of interest: None