1Department of Paediatrics, Sri Venkateshwaraa Medical College Hospital and Research Centre, Ariyur, Puducherry.
Background: The most frequent type of seizures in children are febrile seizures (FS), which are usually brought on by infections that cause the body to heat up quickly. There is growing evidence that electrolyte imbalances, especially low serum sodium, may affect their frequency and intensity. Muscle contraction, nerve transmission, and fluid balance all depend on serum sodium levels. In order to better understand how electrolyte imbalances impact seizure dynamics and to guide therapeutic techniques that address fever and underlying electrolyte problems, this study investigates the link between sodium levels and FS outcomes.
Methodology: The purpose of this prospective observational study was to assess the clinical profile of 106 children between the ages of 6 and 60 months who had febrile seizures and ascertain whether serum sodium levels were linked to seizure recurrence within 24 hours. Every patient had fever, uncontrollable movements, and almost all of them rolled their eyes.
Results: Seizures recurred in 27.4% of cases. Recurrence was significantly correlated with male gender, history of seizures, and low serum sodium levels (hyponatremia). 75.9% of people with recurrent seizures were men, 62.1% had a history of seizures, and 69% had hyponatremia. The mean serum sodium level was statistically significantly lower in those with recurrent seizures than in those without (130.86 vs 135.17 mmol/L). Serum potassium, age, seizure length, vital signs, and immunization status were among the other factors that did not significantly correlate with seizure recurrence.
Conclusion: These findings suggest that hyponatremia and male gender are key predictors of early recurrence in febrile seizures.
Keywords: Febrile seizures, fever, hyponatremia, serum sodium levels.
How to cite this article: Gauthaman B, Kulandaivel M, Latha V, Kalaimani T, Manoharan E. Clinical Profile of Febrile Seizure and its Special Reference to Serum Sodium - A Prospective Observational Study. Int J Drug Deliv Technol. 2026;16(15s): 605-613. DOI: 10.25258/ijddt.16.15s.71
Source of support: Nil.
Conflict of interest: None