1Assistant Professor, Department of Pharmacy Practice, Santhiram College of Pharmacy, Nandyal, 518501, Andhra Pradesh
2Research Scholar, Department of Pharmacy Practice, Santhiram College of Pharmacy, Nandyal, 518501, Andhra Pradesh
Preeclampsia remains a major cause of maternal and perinatal morbidity and mortality globally. In an effort to determine aspirin's place in preventing it, this study examined the efficacy and safety of low dose aspirin, especially in high-risk pregnancies. Aspirin effectiveness and risks involved in its use must be assessed among various populations. This Retro-Prospective study was carried out for six months, involving pregnant women who had been exposed to aspirin and followed up for the onset of preeclampsia. Clinical information on 140 pregnant women was assessed, with participants divided into aspirin-exposed and unexposed groups. They included 51 patients who are treated with aspirin but didn't develop preeclampsia, 19 patients who are treated with aspirin and developed preeclampsia, 57 patients who weren't treated with aspirin and developed preeclampsia, and 13 patients who neither treated with aspirin nor developed preeclampsia. Maternal demographics, APGAR (Appearance, Pulse, Grimace, Activity, Respiration), aspirin use, blood pressure, and clinical outcomes data were gathered. Chi square test and Mann-Whitney U tests were used for the data analysis. Of the 70 aspirin users, 51(72.9%) remained free from preeclampsia, whereas only 13(18.5%) of 70 non-aspirin users were free from preeclampsia, indicating an appreciable decline in incidence. Statistical analysis (p<0.05) validated significant intergroup differences in efficacy. There were no severe adverse events due to the use of aspirin, which further established its safety profile. The results prove aspirin to be both efficacious and safe for preeclampsia prophylaxis in high-risk pregnant women, providing worthwhile evidence for its routine clinical application.
Keywords: Preeclampsia, Aspirin, Safety, Effectiveness, APGAR.
How to cite this article: Reddy MNR, Swapna M, Fareeha SC, Surendra G, Kusha Bai M. EFFECTIVENESS OF ASPIRIN ON PREVENTION OF PREECLAMPSIA AND NEONATAL MORBIDITY: A RETRO PROSPECTIVE STUDY IN TERTIARY CARE TEACHING HOSPITAL. Int J Drug Deliv Technol. 2026;16(15s): 788-795. DOI: 10.25258/ijddt.16.15s.88
Source of support: Nil.
Conflict of interest: None