1Chitkara College of Pharmacy, Chitkara University, Punjab, India
2Department of Pharmaceutical Sciences, MDU, Rohtak, Haryana
Boerhavia diffusa (Punarnava) is a well-known medicinal plant that is characterized by a variety of pharmacological effects and a wide range of applications in the systems of traditional medicine. The current review thoroughly discusses the phytochemical, ethnopharmacological, and therapeutic potential of B. diffusa, diuretic, hepatoprotective, anti-inflammatory, anti-oxidant, anti-fibrinolytic, anti-cancer, anti-diabetic, immunomodulatory and anti-microbial effects. These biological actions are mediated by a number of pathways including the adjustment of cellular signaling pathways, prevention of inflammatory mediates, improvement of antioxidant defenses, and control of apoptosis and angiogenesis. Besides its therapeutic importance, the review has also pointed out the new evolving surveys that have been developed in the experimental and preclinical research on its effectiveness. Moreover, the changing regulatory systems of the herbal products in the key areas of the world are reported in a specific section with the focus on the issues related to the standardization, quality control, and clinical validation. Even though its medicinal potential is promising, the problem of inconsistency in phytochemical composition and absence of regulatory measures to harmonize it are significant challenges to the global acceptance of the product. In general, B. diffusa is a promising natural resource with massive potential to develop as a source of the future drugs, and therefore, the research should be further developed, clinically validated and regulated to guarantee the safety and efficacy of its therapeutic benefits.
Keywords: Boerhavia diffusa, medicinal plant, bioactive compounds, therapeutic potential.
How to cite this article: Sahin N, Kamal R, Singh TG, Dhiman S, Dureja H. Herbal product Development Perspective of Boerhavia diffusa: Challenges in Standardization and Regulation. Int J Drug Deliv Technol. 2026;16(15s): 826-839. DOI: 10.25258/ijddt.16.15s.93
Source of support: Nil.
Conflict of interest: None