Metallic Nanoparticles in Drug Delivery: Toxicity and Biodegradability Considerations

Bipin Sule ¹, Vishal Biswas ², Dr. Amol Shete ³, Dr. Dilip Hinge ⁴, Sandeep Prakash Saini ⁵

¹Senior Professor Department of DESH Vishwakarma Institute of Technology Pune, Maharashtra – 411037, India Email: bipin.sule@vit.edu
²Assistant Professor School of Allied Health Sciences Noida International University Uttar Pradesh – 203201, India Email: vishal.biswas@niu.edu.in
³Associate Professor Department of Pharmaceutics Krishna Institute of Pharmacy Krishna Vishwa Vidyapeeth (Deemed to be University) Taluka-Karad, Dist-Satara – 415539 Maharashtra, India Email: amol.shete@rediffmail.com
⁴Assistant Professor Krishna Institute of Science and Technology Krishna Vishwa Vidyapeeth (Deemed to be University) Taluka-Karad, Dist-Satara – 415539 Maharashtra, India Email: ddhinge@gmail.com
⁵Assistant Professor Department of Pharmacology Arya College of Pharmacy Jaipur, Rajasthan, India Email: sandeep.prakash@aryajaipur.com

ABSTRACT

Metal nanoparticles (MNPs) are becoming more and more interesting as possible drug delivery systems because they have special physical and chemical properties, such as a large surface area, low cost, and the ability to carry a lot of therapeutic agents. Because of these features, MNPs are very good at targeting particular tissues, making drugs more bioavailable, and making different treatments more efficient. But the growing use of MNPs in biomedical settings makes people worry about how toxic they might be and how long it will take for them to break down in the body. MNPs' toxicity depends on many things, such as their size, shape, surface charge, composition, and changes made to their surface. Even though MNPs can be very helpful in therapy, too much of them in living things can have bad effects, like oxidative stress, inflammation, and problems with how cells work. These nanoparticles can affect many systems, mainly the lungs, kidneys, and liver, based on how they are delivered and what kind of particles they are. Also, knowing how MNPs interact with immune systems and cell membranes is important for reducing their harmful effects and making sure that drug delivery applications are safe. Biodegradability is another important thing to think about when judging MNPs for drug delivery uses. Unlike other drug carriers, MNPs need to be made so that they break down into harmless byproducts once they've done their job. Most of the time, biodegradable MNPs are made from biodegradable plastics or metal alloys that can break down using chemical or biological processes. Biodegradation that works well lowers the chance that particles will build up in tissues for a long time and makes it easier for the body to get rid of them, so there is little damage to the environment

Keywords: Metallic nanoparticles, Drug delivery, Toxicity, Biodegradability, Biocompatibility

How to cite this article: Sule B, Biswas V, Shete A, Hinge D, Saini SP, Metallic Nanoparticles in Drug Delivery: Toxicity and Biodegradability Considerations.Int J Drug Deliv Technol. 2026;16(1s): 83-91; DOI: 10.25258/ijddt.16. 83-91