Abamectin, a widely used macrocyclic lactone pesticide, has raised concerns regarding its potential toxic effects on mammalian systems. This study aimed to evaluate the impact of abamectin on reproductive hormones, hepatic and renal biomarkers, and oxidative stress parameters in female rats. Adult female Wistar albino rats were divided randomly into two groups of ten each. The first untreated group (control) was orally given distilled water. The second (treated) group was orally administered abamectin at 2.18 mg /kg for 21 days. Abamectin exposure significantly increased serum prolactin, FSH, LH, and testosterone (p 0.05), indicating endocrine disruption. Hepatic and renal biomarkers (AST, ALT, ALP, GGT, urea, and creatinine) were markedly elevated, suggesting hepatotoxicity and nephrotoxicity. Furthermore, GSH content and activities of SOD and CAT were significantly reduced in all examined tissues, accompanied by a notable rise in MDA and NO levels (p 0.05), confirming oxidative and nitrosative stress.These findings suggest that the abamectin has caused infertility in female rats. Abamectin induces multi-organ toxicity in female rats through endocrine disruption, hepatic and renal dysfunction, and oxidative/nitrosative stress. Therefore, it is recommended to highlight the need for stricter regulation of abamectin use and further research into protective strategies against its toxic effects
Keywords: Abamectin, Antifertility, Rats, pest control.
How to cite this article:El-Arably WMH, Ashry M, Wilson M, Hamad N, Moustafa MA., Evaluating The Antifertility Effects of Abamectin on Female Albino Rats .Int J Drug Deliv Technol. 2026;16(1s): 885-892; DOI: 10.25258/ijddt.16. 885-892