Mesoporous Silica Nanoparticles for Drug Encapsulation

Kuldeep Bansal ¹, Kapil Mundada ², Vratika Arya ³, Dr. Narendrakumar J. Suryavanshi ⁴, Dr. Amar Mohite ⁵, Ms. Aishwarya D. Jagtap⁶

¹Assistant Professor Department of Pharmaceutical Chemistry Arya College of Pharmacy Jaipur, Rajasthan, India Email: kuldeep.bansal@aryajaipur.com
²Associate Professor Department of Instrumentation and Control Engineering Vishwakarma Institute of Technology Pune, Maharashtra – 411037, India Email: kapil.mundada@vit.edu
³Assistant Professor School of Allied Health Sciences Noida International University Uttar Pradesh – 203201, India Email: vratika.arya@niu.edu.in
⁴Assistant Professor Krishna Institute of Science and Technology Krishna Vishwa Vidyapeeth (Deemed to be University) Taluka-Karad, Dist-Satara – 415539 Maharashtra, India Email: njsuryawanshi1981@gmail.com
⁵Assistant Professor Krishna Institute of Science and Technology Krishna Vishwa Vidyapeeth (Deemed to be University) Taluka-Karad, Dist-Satara – 415539 Maharashtra, India Email: armohitept@gmail.com
⁶Assistant Professor Krishna Institute of Science and Technology Krishna Vishwa Vidyapeeth (Deemed to be University) Taluka-Karad, Dist-Satara – 415539 Maharashtra, India Email: aishwarya22999@gmail.com

ABSTRACT

Because of its unique structural qualities a high surface area, pore diameters that may be altered, and biocompatibility mesoporous silica nanoparticles (MSNs) are attracting a lot of interest in the field of drug delivery. These features make MSNs ideal for enclosing medicinal substances and releasing them gradually. MSNs may be created to carry many different medications, including ones that either dislike water or ones that do. Their porous structure enables several medicinal molecules fit within. Surfaces of MSNs can also be altered to target certain cells or tissues, increase their stability, and assist in drug carrying capacity. MSNs have therefore been developed as effective means of delivering a variety of therapeutic drugs, including cancer therapies, gene therapy, and antibiotics. MSNs are among the finest as they allow encapsulated pharmaceuticals to remain unbroken. This maintains the medicinal agent's stability till it reaches its intended spot. Drug release from MSNs can frequently be triggered by external cues such variations in pH, temperature, or light. This allows one to control the release rate of medications. Targeting moieties to the surface of medications, such as peptides or antibodies, helps them to be delivered specifically to certain cells, therefore improving the therapeutic efficiency and lowering adverse effects. Though MSN-based medication delivery systems provide several advantages, their practical deployment is currently challenging. Among these issues include development, long-term safety, and maybe injury. Still, researchers are working hard to discover solutions to these challenges; MSNs are still viewed as a valuable and robust resource for developing improved drug delivery systems that may be applied in a range of therapeutic environments

Keywords: Mesoporous silica nanoparticles, drug delivery, controlled release, surface functionalization, targeted therapy

How to cite this article: Bansal K, Mundada K, Arya V, Suryavanshi NJ, Mohite A, Jagtap AD, Mesoporous Silica Nanoparticles for Drug Encapsulation.Int J Drug Deliv Technol. 2026;16(1s): 92-100; DOI: 10.25258/ijddt.16. 92-100