Conventional treatments for brain disorders are limited due to poor drug solubility and the blood-brain barrier. This study developed a transethosomal in situ gel to leverage high vesicle deformability for enhanced penetration and sustained neuroprotective release. A transethosomal in situ gel loaded with a phytopharmaceutical combination of Withania somnifera (Ashwagandha), Bacopa monnieri (Brahmi), and Cynodon dactylon (Durva) were prepared via thin-film hydration using soy lecithin, cholesterol, and Tween-80. Characterization included Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), and entrapment efficiency (EE) analysis. The optimized vesicles were incorporated into an in situ gel and evaluated for pH, viscosity, rheological properties, and in vitro drug release. SEM confirmed spherical, well-defined transethosomes. FTIR spectra indicated no drug-excipient interactions, confirming chemical stability. The optimized vesicles exhibited a high EE of 85.2% and a sustained cumulative release of 82.5%. The final gel demonstrated a physiological pH of 6.4 and a viscosity of 3000 cP, indicating suitable properties for localized application. The developed transethosomal in situ gel effectively combines high entrapment with favorable release kinetics. This system represents a promising platform for the delivery of bioactive herbal compounds in managing chronic neurodegenerative conditions..
Keywords: Polyherbal, Transethosomes, in-situ gel, thin film hydration and neurodegenerative disease
How to cite this article:Gauri, Singh MP, Singh J, Goyal A, Development and Evaluation of Transethosomal loaded Polyherbal in situ Gel for Extended Permeability in the Management of Neurodegenerative Disease.. .Int J Drug Deliv Technol. 2026;16(1s): 1129-1135; DOI: 10.25258/ijddt.16. 1129-1135