Agricultural biotechnology has been transformed by enabling exact and quick gene alteration of crops with CRISpen-based genome editing technology. Knowing how to change certain genes in plants might help to greatly enhance food quality, disease prevention, and agricultural output. This research aims to evaluate their possibilities as well as their difficulties and how CRISpen-Cas9 and other CRISpen-based technologies may be used to improve crops. Excellent for changing genes, CRISpen-Cas9 may target specific DNA regions in many different living beings, including plants. Using this approach, foods better equipped to resist biotic and abiotic stresses, have greater nutritional value, and produces more are being grown in agriculture. Creating crops resistant to problems brought on by climate change including drought, heat, and salt of soil is among the most hopeful uses. Using CRISpen-Cas9, basic meals have also become healthier by integrating extra proteins, vegetables, and minerals our systems need. Growing food that are resistant to pests and illnesses is also made feasible by Crispen technology. Consequently, farming is more ecologically friendly and chemical herbicides are not as much required. Although changing genomes in agriculture using CRISpen offers a lot of amazing potential, there are several issues as well. Still major factors influencing their lack of mainstream adoption include regulation issues and general concerns over the safety of genetically modified crops. Using CRISpen technology raises moral questions as well, particularly with relation to gene drive systems that may alter wild plant groupings' genomes in an irreversible manner. Also, problems with technology like changes that happen in the wrong places, how well gene editing works in some plant species, and the long-term effects on the environment of genetically modified foods need to be fixed. This review talks about the latest progress and plans for the future of using CRISPR to change the genomes of crops. The review also points out areas that need more study and development, especially when it comes to making CRISPR tools more useful and accurate and figuring out how to work with legal systems. Overall, CRISPR-based gene editing shows a lot of promise for changing the way farming is done and making sure there is a steady supply of food in the face of world problems.
Keywords: CRISPR-Cas9, Genome editing, Agricultural biotechnology, Crop improvement, Food security
How to cite this article:Hinge D, Jadhav AV, Sharma S, Bhise S, Bansal K., CRISPR-Based Genome Editing in Agricultural Crops: A Review .Int J Drug Deliv Technol. 2026;16(1s): 1161-1176 DOI: 10.25258/ijddt.16. 1161-1176