Spray drying can produce tiny, homogeneous powders with regulated properties, which is why many pharmaceutical drugs are made using technique. This technique turns a liquid medication solution or combination into small particles using a heated gas stream. Quick solvent evaporation leaves dry particles behind. The procedure is quite adaptable and may be applied with several kinds of pharmacological preparations, including proteins, vaccines, and compounds not well soluble in water. Making lipophilic medicines more soluble and accessible depends much on the capacity to employ spray drying to produce amorphous solid dispersion. Furthermore made feasible by technology are sustained-release formulations, which help patients to follow their treatment programs and help to lower their requirement for regular dosage. Several factors, such as the feed content, the input air temperature, the tip type, and the spray rate, can be changed to make the spray drying process fit your needs. These factors have a big effect on the shape, size distribution, and surface qualities of the particles that are made. This lets the drug release profiles and stability be optimised. Also, spray-dried mixtures can be put inside vehicles or mixed with other substances to make the drugs more stable, stop them from sticking together, and make sure they release slowly. It is very important to think about how well the drug and excipient work together during product creation to avoid bad chemistry interactions. While it has many benefits, there are some problems that need to be carefully solved, such as how to make it more efficient, how to make the manufacturing features work better, and how the drying conditions affect the purity of the drug. Concerns about safety and the environment must also be taken into account when using chemical solvents in some spray-drying methods. Spray-drying technologies that are more environmentally friendly and effective are still being studied. For example, supercritical fluids and new carriers are being used in study
Keywords: Spray drying, drug formulation, bioavailability, solid dispersions, pharmaceutical technology
How to cite this article: Joginder J, Jain S, Sarkale PS, Ghatage A, Kurulekar M, Spray Drying in Drug Formulation: A Technological Overview .Int J Drug Deliv Technol. 2026;16(1s): 110-118 DOI: 10.25258/ijddt.16. 110-118