Studies from recent times show that male reproductive health deterioration links to chemical contamination found in environmental and workplace settings. The widespread use of synthetic substances during the past few decades has led to a significant decrease in sperm quality and hormonal balance. The presence of these pollutants, numerous in their potential to disrupt endocrine functions, has sparked significant apprehension regarding their lasting effects on fertility and overall population health. A comprehensive search was conducted in the PubMed, Scopus, and MEDLINE databases using terms such as environmental pollutants, male infertility, endocrine disruptors, oxidative stress, and spermatogenesis. Research conducted from 1990 to 2025 has been revivewed and analyzed to outline the underlying mechanisms of disease and the results related to reproduction. Research shows that phthalates and bisphenols and pesticides and flame retardants disrupt the hypothalamic–pituitary–gonadal axis while blocking steroid production and creating oxidative stress that affects sperm shape and motility. The research shows that exposure to pollutants leads to male infertility according to the overall evidence despite varying results from different studies with different methods and participant groups. Environmental and occupational pollutants significantly impact the decline in male fertility. The protection of reproductive health requires three essential elements which include enhanced biomonitoring and strong regulatory systems and specific national research initiatives in Kyrgyzstan..
Keywords: Male infertility; Environmental pollutants; Endocrine disruptors; Oxidative stress; Spermatogenesis
How to cite this article:Paizildaev T, Kalmatov R, Ismailov I, Baigashkaev E, Momunova A., Primary Mechanisms of Environmental Pollutant-Induced Male Reproductive Disorders: AN updated literature review...Int J Drug Deliv Technol. 2026;16(1s): 1278-1287; DOI: 10.25258/ijddt.16. 1278-1287