Lipophilic drug delivery systems (LDDS) have gotten a lot of attention in pharmaceutical research because they can make drugs that don't dissolve well in water more bioavailable. These systems are mostly about making lipophilic chemicals more stable and soluble, which solves problems that regular drug transport methods have. This study talks about the different ways that LDDS can be made and how well they work, focussing on how they can improve the effectiveness of therapies. The piece talks about different methods, such as solid lipid nanoparticles (SLNs), liposomes, nanoemulsions, and lipid-core micelles. These all help to effectively encapsulate drugs that don't like water. LDDS preparation depends on a number of important factors, such as picking the right lipids, detergents, and excipients to keep the drug stable and release it slowly. These systems can offer focused or continuous release, which keeps beneficial drug amounts high for longer periods of time with fewer side effects. Since the LDDS parts directly affect the safety profile of the system, their biocompatibility is quite crucial. New lipid-based carriers developed as nanotechnology has advanced let medications enter cells and distribute about them more readily. Different in vitro and in vivo studies are conducted to examine factors like drug release, stability, and metabolism in order to ascertain how effectively LDDS performs. While in vivo studies illustrate how the drug is absorbed, distributed, broken down, and removed (ADME), in vitro release patterns are frequently utilised to project what would happen in the real world.
Keywords: Lipophilic drugs, drug delivery systems, bioavailability, formulation strategies, lipid-based carriers
How to cite this article: Kimothi S, Ramtirthkar CR, Garg V, Ghewari P, Durgawale P, Lipophilic Drug Delivery Systems: Formulation and Performance .Int J Drug Deliv Technol. 2026;16(1s): 119-127 DOI: 10.25258/ijddt.16. 119-127