Niosomes as Drug Carriers: Self-Assembly and Stability

Mrs. Jisha Annie Geevarghese ¹, Mrs. Pratiksha Jadhav ², Kiran Ingale ³, Om Prakash Sharma ⁴, Anjali Rawat ⁵

¹Assistant Professor Department of Pharmacy Practice Krishna Institute of Pharmacy Krishna Vishwa Vidyapeeth (Deemed to be University) Taluka-Karad, Dist-Satara – 415539 Maharashtra, India Email: kipjishaannie22@gmail.com
²Assistant Professor Department of Pharmacology Krishna Institute of Pharmacy Krishna Vishwa Vidyapeeth (Deemed to be University) Taluka-Karad, Dist-Satara – 415539 Maharashtra, India Email: panchashilanirmale@gmail.com
³Assistant Professor Department of E&TC Engineering Vishwakarma Institute of Technology Pune, Maharashtra – 411037, India Email: kiran.ingale@vit.edu
⁴Associate Professor Department of Pharmaceutics Arya College of Pharmacy Jaipur, Rajasthan, India Email: om.prakash@aryajaipur.com
⁵Anjali Rawat Assistant Professor School of Allied Health Sciences Noida International University Uttar Pradesh – 203201, India Email: anjali.rawat@niu.edu.in

ABSTRACT

Non-ionic surfactant-based vesicular systems called nanosomes have gotten a lot of attention in drug transport because of their unique structure, adaptability, and ability to work with living things. These self-assembling vesicles, which are made up of detergents, cholesterol, and sometimes charge-inducing agents, are much better than regular liposomes because they are more stable, easier to make, and cheaper. The packaging and controlled release qualities of nanosomes are very good, and they can give a wide range of medicinal agents, including proteins, peptides, nucleic acids, and drugs that are hydrophilic or lipophilic. Dynamic in nature, niosomes self-assembly is the process by which surfactant molecules stick together in water to create two-layer structures driven forward by interactions between molecules that either like or dislike water. To vary the size and characteristics of niosomes, alter the surfactant mix, lipid ratio, and fabrication technique. Niosomes may be produced from many techniques including liquid injection, reverse-phase evaporation, and film hydration. Every one of these influences their stability as well as their molecular encapsulating quality. Natural stability of niosomes results from their flexible surfactant molecules. They are thus an excellent choice for medication delivery systems as they allow them to respond to various physiological circumstances. Many factors influence the stability of niosomes: surfactant type, presence of stabilising chemicals, temperature, pH, etc. Their therapeutic efficacy is largely derived on their stability in the body, during storage, and during application to certain sites. Changing the surfactant mix and adding stabilisers has been shown by researchers to help niosomes remain more stable over time, therefore improving their ability to carry pharmaceuticals..

Keywords: Niosomes, Drug Delivery, Self-Assembly, Stability, Surfactants

How to cite this article: Geevarghese JA, Jadhav P, Ingale K, Sharma OP, Rawat A, Niosomes as Drug Carriers: Self-Assembly and Stability .Int J Drug Deliv Technol. 2026;16(1s): 128-135 DOI: 10.25258/ijddt.16. 128-135