Floating Drug Delivery Systems (FDDS) are a new way to give drugs by mouth that are meant to make drugs more bioavailable by giving them more time to stay in the stomach. The idea behind FDDS is to create a drug carrier that floats in the stomach. This lets the drug be released slowly and constantly over a long period of time. In some cases, this can make medicines work better, especially ones that are hard to absorb or are meant to work only in the stomach. Certain ingredients, like hydrocolloids, gas-generating agents, and polymers, give the system its buoyancy. These make it possible for the mixture to sit on top of the stomach's surface. There are several benefits to FDDS, such as limited drug release, less drug breakdown in the acidic gut, and better patient cooperation because the drug doesn't have to be given as often. Even though there might be benefits, the creation of FDDS meets many problems. The design of the mixture is very complicated, and the excipients must be carefully chosen to keep the drug's buoyancy and control its release. The system's function can be changed by things like the amount of food eaten, the pH of the stomach, and the effect of gastrointestinal movement. Another big problem is that it's hard to make these systems work better and cheaper when they are used on a larger scale for industrial production. Also, problems with regulations and differences between patients, like having stomach diseases or having their gastric emptying rates change, might make it hard for FDDS to be widely used in clinical settings..
Keywords: Floating Drug Delivery Systems (FDDS), Bioavailability, Controlled Release, Gastric Residence Time, Drug Formulation, Polymeric Materials
How to cite this article: Raikwar R, Khan A, Patil SS, Inamdar S, Sharma NK, Patil BK, Floating Drug Delivery Systems: Principles and Challenges .Int J Drug Deliv Technol. 2026;16(1s): 136-143 DOI: 10.25258/ijddt.16. 136-143