Traditional management of medical gas production and distribution in the sector is characterized by high dependence on physical documentation, manual administrative processes, and limited real-time traceability, which increases operational risks, costs, and regulatory compliance gaps. This article presents a comprehensive model that combines the integration of medical and industrial gases with complete digitalization of production, logistical, and documentary processes. The model incorporates digital twins, custom software for order management, real-time delivery control, web platforms for customers, and the elimination of physical documents such as dispatch notes and loan contracts. Additionally, the modification and optimization of the production plant and its processes are addressed through the implementation of digital twins and 3D modeling, enabling technical and operational comparison with practices employed by multinational gas companies and the Colombian pharmaceutical industry. Likewise, the reconfiguration of distribution routes is analyzed based on Antioquia’s geography, differentiating logistical strategies for the metropolitan area and areas outside it, in order to improve efficiency, service timeliness, and safety during transportation. Finally, the study demonstrates a significant change in the perception and trust of industrial gas customers, derived from the adoption of operational and quality protocols aligned with Good Manufacturing Practices (GMP) principles. The results demonstrate significant improvements in operational efficiency, reduction of administrative burden, increased customer reliability, and strengthened traceability, providing technical evidence for sector modernization and updating of the Colombian regulatory framework...
Keywords: digital twins, medical gas, industrial gas, gas production, 3D modelling
How to cite this article: Marín Duque DM, Restrepo Gaviria LD, Vélez Ruiz LM, García Arango DA, Acosta Agudelo LC, Montoya Escobar CM., Technological, Operational, Logistical, and Digital Integration in the Production and Distribution of Medical and Industrial Gases in Antioquia: An Approach Based on GMP, Digital Twins, and Intelligent Information Management...Int J Drug Deliv Technol. 2026;16(1s): 200-207; DOI: 10.25258/ijddt.16. 200-207