Liposome-Based Drug Delivery Systems: Mechanisms and Applications

Mr. Anup Patil ¹, Mr. Shivsharan Dhadde ², Avinash Somatkar ³, Soniya Sharma⁴, Mohammad Yasin ⁵

¹Asso. Professor, Dept. of Pharmacology Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth “Deemed to be University”, Taluka-Karad, Dist-Satara, Pin-415 539, Maharashtra, India Email : anuppatil.pharma@gmail.com
²Asst. Professor, Dept. of Pharmacology Krishna Institute of Pharmacy,  Krishna Vishwa Vidyapeeth “Deemed to be University”,  Taluka-Karad, Dist-Satara, Pin-415 539, Maharashtra, India Email : sbdhadde@hotmail.com
³Assistant Professor, Department of Mechanical Engineering, Vishwakarma Institute of Technology, Pune, Maharashtra, 411037 email ID : avinash.somatkar@vit.edu
⁴Assistant Professor,School of Allied Health Sciences,Noida International University,Uttar Pradesh 203201,India. soniya.sharma@niu.edu.in
⁵Assistant Professor,Department of Pharmacology, Arya College of Pharmacy,Jaipur, Rajasthan, India. mohammad.yasin@aryajaipur.com

ABSTRACT

Drug delivery systems based on liposomes (DDS) have become a very flexible and useful way to send drugs precisely in the pharmaceutical sciences. Liposomes are round bubble-like structures made up of two layers of lipids. They are used to keep both water-loving and water-hating drugs from breaking down and improve their solubility. Liposomes' special structure lets drugs be released in a controlled way, which is important for making treatments work better while reducing side effects. It is possible to program these systems to target certain cells or organs, which makes focused treatment possible for illnesses like cancer, infections, and inflammatory disorders. There are two main ways that liposomes transport drugs: passive targeting through the increased permeability and retention (EPR) effect and active targeting made easier by surface changes like ligand conjugation. Because of the leaking capillaries, the EPR effect makes it possible for liposomes to gather more in tumour tissues. This increases the concentration of the drug at the target spot. When you use ligands like antibodies or peptides to bind to receptors that are overexpressed on target cells, active targeting makes it more specific. Liposomes are also made to get past biological hurdles like cell walls, enzymes that break down proteins, and the immune system's quick clearance. This makes the half-life of drugs in liposomes longer in the bloodstream. Researchers are looking into different liposomal forms, such as hidden liposomes and thermosensitive liposomes, to improve the effectiveness of targeting and treatment results even more. More and more, these systems are being used to give cancer drugs, vaccines, and gene treatments, which shows hope for better patient results..

Keywords: Liposome-based drug delivery, targeted therapy, controlled drug release, enhanced permeability and retention, biopharmaceutical applications.

How to cite this article: Patil A, Dhadde S, Somatkar A, Sharma S, Yasin M, Liposome-Based Drug Delivery Systems: Mechanisms and Applications .Int J Drug Deliv Technol. 2026;16(1s): 26-33; DOI: 10.25258/ijddt.16. 26-33