Breadfruit (Artocarpus altilis) (Parkinson) Fosberg leaf is a traditional medicine with various properties that have been scientifically validated. The primary constituents of this leaf are flavonoids and phenolics, which contribute to the pharmacological activity. These compounds can not penetrate biological membranes due to their polar nature. Therefore, this study aimed to determine the optimum nanoemulsion formula of breadfruit leaf extract (NE-EDS) that enhances stability and facilitates its penetration through biological membranes. Nanoemulsion (NE) was designed using a 22 factorial design with Tween 80 as the surfactant and 96% ethanol as the cosurfactant. The effect of factor composition and interaction on the nanoemulsion characteristics was observed based on pH, density, viscosity, percent transmittance, and flavonoid content in NE-EDS. The optimum formula of nanoemulsion was produced at a concentration of Tween 80 and ethanol (40%:20%), with a globule size of 246.1±29.44 nm, polydispersity index (PDI) of 0.36±0.06, and zeta potential of -12.6 mV, respectively. The result showed that NE-EDS had good stability. The optimum NE-EDS formula exhibited stable globule characteristics and could be further developed into a topical dosage form..
Keywords: Cosurfactant; Nanoemulsion; Optimum formula; Stability; Surfactant; Tween 80
How to cite this article: Fitrya F, Elfita E, Fithri NA, Apriani EF, Ahmadi A, Nadila DP, Nanoemulsion Of Breadfruit (Artocarpus Altilis) (Parkinson) Fosberg Leaf Extract: Optimization Of Tween 80 And Ethanol Concentration Using Factorial Design..Int J Drug Deliv Technol. 2026;16(1s): 269-275; DOI: 10.25258/ijddt.16. 269-275