The goal of this study was to making an orodispersible drug delivery system suitable for dysphagia patients, this kind of patients do not cooperate with this emergency conditions, like seizures. The starch was chemically modified through chloroacetylation and hydrazinolysis to give acetyl hydrazine starch which is the novel superdisintegrant. The structural confirmation was accomplished using ¹H NMR, ¹³C NMR and FTIR spectroscopy, though XRD and DSC analyses characterized the thermal behavior and crystallinity. SEM can show different morphological changes associated with native starch. The modified starch exhibited markedly improved swelling capacity and cold-water solubility. Orodispersible films (ODFs) containing midazolam as API were fabricated by solvent casting, incorporating the modified starch as a superdisintegrant. The ODFs demonstrated suitable mechanical properties, disintegration within 30 s, and >80% drug release within 1 min. These findings establish acetyl hydrazine starch as a promising new superdisintegrant for ODFs, offering significant potential in emergency drug delivery applications.
Keywords: Poly acetyl hydrazine grafted starch, Polymer modification, Superdisintegrant, Orodispersible film, Oral fast dissolving film, Anticonvulsant therapy.
How to cite this article: Jadhav R, Patil M, Darwajkar A, Sawant C; Quick-Acting Midazolam Films for Acute Seizures: Enhanced Emergency Delivery using Acetyl Hydrazine Starch as Superdisintegrant.Int J Drug Deliv Technol. 2026;16(1s): 572-583; DOI: 10.25258/ijddt.16. 572-583