Sepsis represents a life-threatening condition characterized by a dysregulated host response to infection, resulting in organ dysfunction and accounting for millions of deaths globally each year. The heterogeneity of clinical presentation necessitates a multimodal diagnostic approach and coordinated multidisciplinary management strategies. Early recognition and prompt intervention within the first hour of sepsis presentation significantly improve survival outcomes. This comprehensive review synthesizes current evidence on sepsis management, emphasizing the critical roles of healthcare professionals across multiple disciplines including nursing staff, pharmacists, emergency medical services personnel, social workers, laboratory specialists, and nursing technicians. The review addresses early recognition strategies utilizing clinical indicators and rapid diagnostic biomarkers, antimicrobial therapy selection based on infection source and local epidemiology, source control interventions, hemodynamic support, and long-term follow-up care for sepsis survivors. Implementation of sepsis alert systems, multidisciplinary sepsis emergency response teams, and adherence to evidence-based bundles has been shown to reduce mortality and hospital length of stay. Post-sepsis syndrome represents an emerging concern requiring rehabilitation strategies and comprehensive multidisciplinary follow-up to optimize quality of life in survivors. This review provides an integrated perspective on sepsis management that acknowledges the interconnected contributions of all healthcare professions essential for optimal patient outcomes.
Keywords: Sepsis, multidisciplinary care, early recognition, biomarkers, antimicrobial stewardship, patient outcomes, theraputic strategies
How to cite this article:Almotawa AF, Alenezi RM, Almuashi AMH, Alotaibi AK, Alshuraymi SS, Alzahrani ZSH, Alqarn KE, Multidisciplinary Management of Sepsis: Early Recognition, Diagnostic Approaches, and Therapeutic Strategies for Improved Patient Outcomes.Int J Drug Deliv Technol. 2026;16(1s): 702-711; DOI: 10.25258/ijddt.16. 702-711