Characterization Of Pva/Collagen Bioscaffold Enriched With Xanthium Strumarum Leaf Extract

Kodali Dhruv Kiran¹, Shantha Sundari KK ² , Swapna Sreenivasagan ³

¹Undergraduate student Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 600077, India. Email : kodalidhruvkiran@gmail.com
² Professor, Department of Orthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 600077, India. Email :shanthakkss@gmail.com
³ Assistant Professor Department of Orthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 600077, India. Email :Swapnas.sdc@saveetha.com

ABSTRACT

Background: Polymeric scaffolds are widely used in tissue engineering due to their ability to mimic extracellular matrix architecture. Polyvinyl alcohol (PVA) provides mechanical stability, while collagen enhances biocompatibility; however, their combination lacks intrinsic bioactivity. Incorporation of plant-derived bioactive compounds may improve the biological and functional performance of such scaffolds. Xanthium strumarium is a medicinal plant known for its antimicrobial and anti-inflammatory properties. Aim: To fabricate and characterize a PVA/Collagen bioscaffold enriched with Xanthium strumarium leaf extract and evaluate its physicochemical, mechanical, and biological properties for potential tissue engineering applications. Materials and Methods: A composite bioscaffold was fabricated using 10% PVA and 1% collagen with methanolic Xanthium strumarium leaf extract and processed via freeze-drying. The scaffold was characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray analysis (EDAX). Mechanical properties were evaluated through tensile strength testing and porosity assessment. Biological performance was assessed by cell viability assays and anti-inflammatory activity through measurement of TNF-α and IL-6 levels. Results: FTIR and XRD analyses confirmed successful incorporation of the plant extract and modification of scaffold crystallinity. SEM revealed a highly porous and interconnected architecture, with EDAX confirming elemental composition. The extract-enriched scaffold demonstrated increased tensile strength and porosity compared to the control scaffold. High cell viability and significant reduction in pro-inflammatory cytokines were observed, indicating good biocompatibility and anti-inflammatory potential. Conclusion: The PVA/Collagen bioscaffold enriched with Xanthium strumarium leaf extract exhibited favorable physicochemical, mechanical, and biological properties, highlighting its potential application in tissue engineering and wound healing...

Keywords: N\A.

How to cite this article:Kiran KD, Sundari SKK, Sreenivasagan S; Characterization Of Pva/Collagen Bioscaffold Enriched With Xanthium Strumarum Leaf Extract..Int J Drug Deliv Technol. 2026;16(1s): 710-713; DOI: 10.25258/ijddt.16. 710-713