Anti-Arthritic Activity Of Hamelia Patens Leaves Extracts In Experimental Animal Model

Mukhtar Yousef bin Ahmed Bohassan¹, Ravi Shankar N², Pramod S², Aadhi Kesavan m³, Pavan Kumar Pavagada Sreenivasalu¹, Sreeharsha Nagarja³

¹Department of Restorative Dental Sciences, College of Dentistry, King Faisal University, Al Ahsa, Saudi Arabia
²Faculty of Pharmacology, Visveswarapura Institute of Pharmaceutical Science, Bengaluru, India
³Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.

ABSTRACT

The foremost objective of this investigation is to evaluate, anti-arthritic effect of Hamelia patens leaf extracts using the in vivo FCA-induced arthritis model and in vitro egg albumin denaturation assay method and in vivo activity was performed using Albino Wistar rats at doses of 200 and 400 mg/kg, with diclofenac sodium (20 mg/kg) used as the standard drug. Arthritis was induced using Complete Freund’s Adjuvant (FCA), and disease progression was evaluated by measuring the rats' paw volume. The in-vitro activity was conducted by the egg albumin denaturation assay model, which displayed a significant, dose related reduction in the paw volume, followed by a decrease in the white cell count and an increase in red cell count. The in-vitro assay further confirmed that dose related inhibition effect of protein unfolding (denaturation) by the leaves extracts. Overall, Hamelia patens demonstrated the potent anti-arthritic activity by reducing the inflammation at the joints, which supports the plants potential effect, as natural remedial agent for the management of arthritis disease.

Keywords: N\A

How to cite this article:Bohassan MYA, Shankar RN, Pramod S, Kesavan AM, Sreenivasalu PK, Nagarja S.; Anti-Arthritic Activity Of Hamelia Patens Leaves Extracts In Experimental Animal Model..Int J Drug Deliv Technol. 2026;16(1s): 727-732; DOI: 10.25258/ijddt.16. 727-732