This study aims to map the development of digitalization toward smart hospitals and analyze how smart infrastructure impacts patient-centered outcomes in the modern healthcare ecosystem. Using a Systematic Literature Review (SLR) method following PRISMA guidelines, this study reviewed 21 articles from Scopus, Web of Science, and PubMed published between 2019 and 2025, focusing on key technologies such as IoT, AI, big data, 5G/6G, digital twins, and hospital digital governance. A thematic analysis was conducted to identify patterns, trends, and research gaps. The results indicate that the evolution of hospital digitalization is influenced by the level of organizational readiness, Health 4.0 strategies, and global technological acceleration. Smart infrastructure, including IoT, AI, big data analytics, high-speed networks, and digital twins, plays a significant role in creating precision care, increasing clinical efficiency, and strengthening doctor-patient communication. At the same time, digital governance and leadership are critical drivers in ensuring technology integration is effective, secure, and aligned with the needs of patient-centered care. Overall, smart technology has a positive impact on service quality, patient safety, patient experience, and hospital operations. These findings imply the need for policy strengthening, digital literacy of healthcare workers, and infrastructure investment as a foundation for sustainable smart hospital transformation. Future research is recommended to examine empirical evidence of implementation in local contexts and evaluate the long-term impact on patient outcomes.
Keywords: smart hospitals, digitalization, Health 4.0, IoT, AI, big data, patient-centered outcomes, digital governance..
How to cite this article:Pramesti LA, Wanasida AS., From Digitalization to Smart Hospitals: A Systematic Literature Review on Intelligent Healthcare Infrastructure and Patient-Centered Care Outcomes..Int J Drug Deliv Technol. 2026;16(1s): 762-771; DOI: 10.25258/ijddt.16. 762-771