1Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati - 517 502, India
2Department of Pharmaceutical Chemistry, Bhaskar Pharmacy College, Hyderabad - 500075, India
*Corresponding author: Doli Sherisha Bhavani, Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati - 517 502, India. Email: sherisha0110@gmail.com
Received: 16th Dec, 2025; Revised: 8th Feb 2026; Accepted: 12th Feb, 2026; Available Online: 28th Feb, 2026
A novel series of ethyl 4-[2-cyano-3-(substituted phenyl)acrylamido]-2-hydroxybenzoates, prepared using a Knoevenagel condensation method. It was reacted by the activation of the methylene group of ethyl 4 (2-cyanoacetamido)-2-hydroxybenzoate and condensed with different substituted benzaldehydes in toluene. High yields were achieved by the use of a catalytic amount of piperidine and acetic acid. In the current study, 1-cyanoacetyl-3,5-dimethylpyrazole was identified to be a cheap and effective starting material to use in the condensation reaction. In general, fifteen compounds could be obtained, purified through recrystallization with ethanol and completely characterized with physical and spectral analysis. The antioxidant potential of the individual compounds (5a-o) was compared, and it was discovered that the compounds with a 3, 4-dihydroxy (5h) substituent on the phenyl ring had the highest antioxidant potential at a concentration of 100 µM compared to others.
Keywords: Ethyl 4-Aminosalicylate, 1-Cyanoacetyl-3, 5-dimethylpyrazole, Knoevenagel condensation
How to cite this article: Bhavani DS, Madhavi K, Synthesis, Characterization and Antioxidant Evaluation of Novel Ethyl 4-[2-cyano-3-(substituted phenyl)acrylamido]-2-hydroxybenzoate Derivatives. Int J Drug Deliv Technol. 2026; 16(2): 339-354; DOI: 10.25258/ijddt.16.2.38
Source of support: Nil.
Conflict of interest: None