1Research Scholars, Department of Pharmaceutics, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai - 116, Tamil Nadu, India.
2Master of Pharmacy, Department of Pharmaceutics, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai - 116, Tamil Nadu, India.
3Assistant Professor, Department of Pharmaceutical Chemistry, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai - 116, Tamil Nadu, India.
4Assistant Professor, Department of Pharmaceutics, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai -116, Tamil Nadu, India.
Hernia is a common surgical procedure that is frequently performed, and there is a demand for effective and biocompatible mesh materials. Standard synthetic meshes are most commonly associated with complications including foreign body response, pain, and infection. Herein we demonstrate the bio-fabrication and In-vitro evaluation of an antibiotic-loaded collagen peptide-polymer composite mesh intended to promote better biocompatibility, mechanical strength, and antimicrobial function. The mesh combines collagen peptides with polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) to give it structural integrity while also including ciprofloxacin for infection control. Characterization approaches such as Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), and water contact angle measurements validate the fabricated mesh's morphology, chemical composition, and hydrophilicity. Tensile strength is maximum with 2.5% polymer concentration, compromising between flexibility and brittleness. Both swelling and biodegradation tests have demonstrated controlled water uptake and degradation for prolonged mechanical support. In-vitro release kinetics show 72.01% ciprofloxacin released in the first 24h followed by first order release ensuring effective antimicrobial protection. Antibacterial tests also confirm a considerable inhibition zone against Staphylococcus aureus and Escherichia coli, indicating sustained bactericidal activity. The biocompatibility, biodegradation and antimicrobial activity of the composite mesh have been improved, and it is expected to be an attractive candidate for replacing traditional synthetic meshes. Advanced fabrication and in-vivo studies should be examined for clinical efficacy. This novel method provides a more patient-friendly alternative for the treatment of inguinal hernia repair with fewer complications and better post-surgical effects due to the proper plane strength, biodegradability, and drug-release.
KEYWORDS: Antibiotics, Antimicrobial efficacy, Collagen peptide, Inguinal hernia, Mechanical Strength, Polymers.
How to cite this article: Sathiyamoorthy R, Rajendran A, Nagaraj RDL, Selvaraj D, Kesavan SK, Formulation And In-Vitro Assessment Of A Collagen Peptide Composite Mesh With An Antibiotic For Inguinal Hernia Repair. Int J Drug Deliv Technol. 2026;16(2): 36-50. DOI: 10.25258/ijddt.16.2.6
Source of support: Nil.
Conflict of interest: None