1Department of School of Pharmaceutical Science, Sandip University, Nashik, Maharashtra 422213, India.
*Corresponding Author: Shubham Varule, Email: shubhsai7834@gmail.com
Background: Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia due to altered insulin secretion or function. Neuropathic pain, a frequent complication, is commonly treated with synthetic drugs like antioxidants, antidepressants, and anticonvulsants, though prolonged use can result in severe adverse effects. Herbal medicines, particularly Chandraprabha Vati, have shown promise in managing diabetes and related complications. While its antidiabetic and anti-obesity effects have been validated in preclinical and clinical studies, its efficacy in diabetic neuropathy remains unexplored.
Methods: The present study evaluated Chandraprabha Vati (CPV) in a high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic neuropathy model in albino rats. Diabetic neuropathy was induced by feeding rats with HFD for eight weeks, followed by STZ injection (35 mg/kg). Normal control animals received a standard chow diet. Treatment groups included a disease control (0.25% Na-CMC), CPV (200 mg/kg), amitriptyline (AMT) (10 mg/kg), and a combination treatment of CPV (100 mg/kg) and AMT (5 mg/kg) for six weeks.
Results: Behavioral tests, viz. heat hyperalgesia, cold allodynia, grip strength, walking function, mechanical hyperalgesia locomotor activity, motor coordination, and oral glucose tolerance test (OGTT), showed significant improvement following treatment with CPV alone and in combination with AMT. Elevated levels of glucose, lipids, oxidative stress marker, MDA were significantly reduced, while insulin and antioxidant levels (SOD, GSH, and catalase) were improved. Altered levels of pro-inflammatory markers (TNF-α, IL-1β and IL-6) were restored by the CPV.
Conclusion: These findings indicate that CPV offers significant therapeutic potential for diabetic neuropathy and also displayed a synergistic effect when combined with the standard drug AMT, thereby presenting a safe and effective alternative to conventional treatments.
Keywords: Diabetes, Diabetic Neuropathy, Chandraprabha Vati, Amitriptyline, High-fat diet, Streptozotocin
How to cite this article: Varule S, Kulkarni A. Protective Role of the Classical Ayurvedic Herbo-mineral Formulation Chandraprabha Vati in Diabetic Neuropathy Induced by High-Fat Diet and Streptozotocin in Rats. Int J Drug Deliv Technol. 2026;16(2): 647-661. DOI: 10.25258/ijddt.16.2.69
Source of support: Nil.
Conflict of interest: None