1Associate Professor, Department of Respiratory Medicine, Jawaharlal Nehru Medical College, KAHER, Belgaum, Karnataka, India
2Senior Resident, Department of Respiratory Medicine, TB Sanitorium, BMCRC, Bellari, Karnataka, India
3Prof and HOD, Department of Respiratory Medicine, Jawaharlal Nehru Medical College, KAHER, Belgaum, Karnataka, India
4Professor, Department of Respiratory Medicine, Jawaharlal Nehru Medical College, KAHER, Belgaum, Karnataka, India
Corresponding Author: Dr. Jyothi Hattiholi, Department of Respiratory Medicine, Jawaharlal Nehru Medical College, KAHER, Belgaum - 590 010, Karnataka, India. E-mail: pulmojyoti@gmail.com
Background and objective: NIV (Noninvasive Ventilation) is one of the most important modality of ventilation which reduces the need for intubation and complications associated with it. However, NIV can not be used in all patients with acute respiratory failure. Hence there is a need to analyse the incidence of failure of NIV and various factors that predict the success and failure of NIV.
Methods: The patients of acute hypoxemic respiratory failure (AHRF) who received NIV were included in study and various parameters such as PaO₂/FiO₂ ratio, A-a O₂ gradient, APACHE II score, SAPS II score, qSOFA score, CURB 65 score were analysed within first 24 hours of admission.
Results: Among 97 patients 53 had favourable outcome and 44 had unfavourable outcome, the incidence of NIV failure was 45.4%. The baseline mean PaO₂/FiO₂ ratio and A-a O₂ gradient was 158.71 and 298.99 respectively. Among those with favourable outcome the mean values were 193.08 and 196.38 and among those with unfavourable outcome the mean values were 117.32 and 422.59 respectively. This was statistically significant. The various other predictors which were studied were APACHE II, SAPS II, CURB 65 and qSOFA scores whose baseline mean values were 17.29, 39.46, 1.83, 1.46 respectively. Among those with favourable outcome the mean values were lower i.e, 13.30, 32.32, 1.77, 1.17 and among those with unfavourable outcome the mean values were higher i.e, 20.59, 49.14, 2.43, 1.70 respectively and this was statistically significant.
Conclusion: This study concludes that one has to have a high index of suspicion of failure of NIV among patients of acute hypoxemic respiratory failure with low PaO₂/FiO₂ ratio, high alveolar arterial gradient (A-a O₂), high APACHE II, SAPS II, CURB 65 and qSOFA scores, as they determine poor prognosis.
KEY WORDS: NIV, AHRF, ARF, PREDICTORS, APACHE II, SAPS II
How to cite this article: Hattiholi J, Viswas T, Patil B, Gaude GS. Predictors of Outcome of Non-Invasive Ventilation in Patients with Acute Hypoxemic Respiratory Failure - A One Year Hospital Based Observational Study. Int J Drug Deliv Technol. 2026;16(2): 677-683. DOI: 10.25258/ijddt.16.2.72
Source of support: Nil.
Conflict of interest: None