Type 2 diabetes mellitus (T2DM) is a major global health problem and a leading contributor to cardiovascular and cerebrovascular morbidity and mortality. Chronic hyperglycaemia in diabetes leads to endothelial dysfunction, platelet activation, and a prothrombotic state. Mean Platelet Volume (MPV), a simple and inexpensive hematological parameter, reflects platelet size and activity and may serve as a potential marker for thrombotic complications in patients with T2DM. The objective is to study the association between Mean Platelet Volume and thrombotic complications—namely coronary artery disease (CAD) and cerebrovascular accident (CVA)—in patients with Type 2 diabetes mellitus, and to compare these findings with non-diabetic patients. This hospital-based cross-sectional observational study was conducted at MGM Medical College and Hospital, Aurangabad, from October 2022 to March 2024. A total of 96 patients were enrolled and divided into two groups: 48 diabetic patients (cases) and 48 non-diabetic patients (controls), all of whom had documented thrombotic events (CAD or ischemic CVA). Detailed clinical evaluation, biochemical investigations including fasting and post-prandial blood sugar, HbA1c, and complete hemogram with platelet indices were performed. MPV was analyzed and correlated with thrombotic complications and glycaemic parameters. Statistical analysis was carried out using SPSS version 20. The majority of patients were above 60 years of age, with male predominance. Mean MPV was significantly higher in diabetic patients compared to non-diabetic controls (p < 0.001). Raised MPV (>11.5 fL) was more frequently observed in diabetic patients with CAD and CVA. A significant association was found between MPV and fasting blood sugar, post-prandial blood sugar, HbA1c levels, and duration of diabetes. No statistically significant difference was observed between cases and controls with respect to age, BMI, hemoglobin, total leukocyte count, platelet count, ECG, or 2D-echocardiographic findings. Mean Platelet Volume is significantly elevated in patients with Type 2 diabetes mellitus and shows a strong association with thrombotic complications and poor glycaemic control. MPV can be used as a simple, cost-effective, and readily available marker to identify diabetic patients at higher risk of cardiovascular and cerebrovascular events, enabling early intervention and improved clinical outcomes.
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How to cite this article: Naik MR, Patel NBI, Ali SA, Naik RC, Ghadge SL, Paramshetti S, Association Of Mean Platelet Volume And Thrombotic Complications In Type 2 Diabetes Mellitus. Int J Drug Deliv Technol. 2026;16(2s): 814-824; DOI: 10.25258/ijddt.16.814-824