Risedronate Sodium has low oral bioavailability and is mainly absorbed in the upper GI tract, requiring a gastro-retentive system for better efficacy. This study developed floating oral in situ gels using Sodium Alginate, HPMC K100M, Carbopol 934P, and Calcium Carbonate to prolong gastric retention and sustain drug release. Ten formulations were evaluated for key properties and drug release. Formulation F6 showed optimal viscosity, gel strength, rapid buoyancy (<30 s), and sustained release (~90% in 12 h) with zero-order kinetics. Stability studies confirmed its robustness. This gastro-retentive gel offers improved bioavailability and patient compliance through once-daily dosing.
Keywords: Gastro-retentive drug delivery; Sodium Alginate; HPMC K100M; Carbopol 934P; Sustained release; Buoyancy
How to cite this article: Talaviya N, Mathukiya Z, Patel S, Patani M, Kalsara K, Soni K, Shah M, Desai R, Upadhyay S, Upadhyay U, Formulation and Evaluation of a Floating Oral In-Situ Gel of Risedronate Sodium for Sustained Gastro-Retentive Drug Delivery. Int J Drug Deliv Technol. 2026;16(2s): 832-850; DOI: 10.25258/ijddt.16.832-850