The development of multifunctional therapeutic agents capable of targeting cancer while mitigating oxidative stress has gained significant attention in recent years. Cancer remains a leading cause of mortality worldwide, often associated with oxidative stress. The development of compounds that combine anticancer activity with antioxidant potential could offer therapeutic advantages. In this study, we report the design and synthesis of a series of novel heterocyclic derivatives based on fused ring scaffolds. These compounds were characterized by NMR, IR, and mass spectrometry. Their biological activities were evaluated for cytotoxicity against human cancer cell lines (MCF-7 and A549) and for antioxidant potential using DPPH and ABTS assays. Several derivatives displayed significant cytotoxicity with IC50 values comparable to reference drugs and showed strong radical scavenging activity. Detailed structure-activity relationships suggest that specific substituents on the heterocyclic core enhance dual activity. These findings support further optimization and in-depth mechanistic studies.
Keywords: Heterocyclic derivatives, anticancer activity, antioxidant activity, synthesis, cytotoxicity, radical scavenging
How to cite this article: Salim MR, Tyagi P, Hunge SS, Parveen S, Dighe SB, KV K, Macha B, Design, Synthesis, and Biological Evaluation of Novel Heterocyclic Derivatives as Dual Anticancer and Antioxidant Agents. Int J Drug Deliv Technol. 2026;16(2s): 126-133; DOI: 10.25258/ijddt.16.126-133