The CRISPR-Cas system has revolutionized gene editing, but its therapeutic application faces delivery challenges, especially within living systems. Nanotechnology has emerged as a transformative tool to enhance CRISPR delivery by improving cellular uptake, stability, and precision targeting. Various nanocarriers-lipid-based, polymeric, inorganic, and biomimetic are being designed to overcome the limitations of viral vectors. These systems facilitate intracellular trafficking, endosomal escape, and nuclear transport of CRISPR elements. Functional customization and stimuli-responsive properties further refine their performance. This review provides a comprehensive overview of platforms and their potential in treating cancers, inherited disorders, and infectious diseases. Emphasis is placed on integrating nanomedicine with precision editing for patient-specific therapies. Advancements in smart nanocarriers may shape the future of minimally invasive, next-generation gene therapies...
Keywords: CRISPR-Cas, Nanotechnology, Gene Editing, Nanocarriers, Targeted Delivery, Genome Engineering
How to cite this article: Yadav AR, Upare MM, Desai SR, Sachdeo RA, Mahamuni SS, Shah NV, Nanotechnology Based CRISPR Delivery Platforms in Therapeutic Genome Engineering. Int J Drug Deliv Technol. 2026;16(2s): 177-184; DOI: 10.25258/ijddt.16.177-184