Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that usually manifests within the first three years of life and affects communication, social interaction, and behaviour. It represents a heterogeneous spectrum of challenges and abilities, varying significantly across individuals. This updated narrative review synthesises global literature of 25 years from 2000 to 2025 to explore the multifaceted challenges experienced by persons affected by ASD, such as social and communication difficulties, sensory processing issues, and the necessity for structured routines. Findings indicate that caregiving stress is exacerbated by financial strain and a lack of rural diagnostic services. Special emphasis is placed on Structured routines, educational strategies, and Palliative care that can be applied to improve the lives of individuals with Autism. The paper aims to serve as a resource for clinicians, educators, and policymakers, fostering early identification, inclusive education, and supportive interventions.
Keywords: Autism spectrum disorder, Early intervention, Neurodevelopmental disorders, Perception.
How to cite this article: Kurup PR, R S, Shah RR, Unni N, SR H, Autism Spectrum Disorder: An Integrative Review of Contemporary Evidence of Challenges, Interventions, and Global Perspectives. Int J Drug Deliv Technol. 2026;16(2s): 212-218; DOI: 10.25258/ijddt.16.212-218