International Journal of Drug Delivery Technology
Volume 16, Issue 2s

Comparative‎‎ Study‎‎ of‎‎ Collagen‎‎ Density‎‎ in‎‎ Reconstruction‎‎ of‎‎ Trachea‎‎ Defects‎‎ with‎‎ Aponeurosis‎‎ Patch‎‎ of‎‎ External‎‎ Oblicus‎‎ Muscle‎‎ and‎‎ Dry‎‎ Amnion‎‎ Membrane‎‎ (A‎‎ Study‎‎ with‎‎ New‎‎ Zealand‎‎ Rabbits)‎‎

Antonio‎‎ Akbar‎‎ Santoso1*,‎‎ Marjono‎‎ Dwi‎‎ Wibowo2,‎‎ Dwi‎‎ Hari‎‎ Susilo2

1Department‎‎ of‎‎ surgery,‎‎ Faculty‎‎ of‎‎ Medicine,‎‎ Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
2Division‎‎ of‎‎ Head‎‎ and‎‎ Neck‎‎ Surgery,‎‎ Department‎‎ of‎‎ Surgery,‎‎ Faculty‎‎ of‎‎ Medicine,‎‎ Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

ABSTRACT

Background: The Reconstruction Of Tracheal Abnormalities Due To Various Clinical Conditions, Such As Trauma, Cancer, And Other Illnesses, Remains A Significant Problem For Surgeons. Dry Amniotic Membrane (Dam) Has Long Been Regarded As A Promising Source Of Scaffold Material, An Essential Element In Tissue Engineering That Serves As A Supportive Matrix For Cellular And Tissue Viability. The Aponeurosis Fascia Is Frequently Employed By Surgeons As A Surgical Patch To Enhance The Efficacy Of Wound Healing In Both Acute And Chronic Wounds.

Objectives: To‎‎ Analize‎‎ Collagen‎‎ Density‎‎ In‎‎ Rabbits‎‎ Undergoing‎‎ Tracheal‎‎ Reconstruction‎‎ With‎‎ The‎‎ External‎‎ Oblique‎‎ Muscle‎‎ Aponeurosis‎‎ Patch‎‎ Alone‎‎ And‎‎ Those‎‎ With‎‎ Dam‎‎ Added.

Methods: This Study Is An Experimental Randomized Controlled Trial Conducted On Male New Zealand White Rabbits. The Rabbits Underwent Acclimatization For Seven Days, After Which Randomization Was Executed Via Permuted Block Randomization To Partition The Samples Into Two Groups. Following The Conclusion Of The Proliferation Period (14 Days), Collagen Density Was Assessed In The Surgical Wound Region Subsequent To Tracheal Restoration. The Data Analysis Was Conducted With Spss Software.

Results: There‎‎ Were‎‎ 16‎‎ Samples‎‎ In‎‎ Each‎‎ Group,‎‎ Group‎‎ With‎‎ Dam‎‎ Procedure‎‎ And‎‎ Control‎‎ Without‎‎ Mak.‎‎ Collagen‎‎ Density‎‎ Was‎‎ Obtained‎‎ In‎‎ Group‎‎ With‎‎ Dam‎‎ Procedure‎‎ (1.00‎‎ (±0.73)‎‎ Cm)‎‎ Compared‎‎ To‎‎ The‎‎ Control‎‎ Group‎‎ Without‎‎ Dam‎‎ (1.85‎‎ (±1.2)‎‎ Cm).‎‎ There‎‎ Were‎‎ Differences‎‎ In‎‎ Collagen‎‎ Density‎‎ In‎‎ The‎‎ Control‎‎ And‎‎ Treatment‎‎‎‎ Groups‎‎ (P‎‎ =‎‎ 0.05)‎‎ Which‎‎ Showed‎‎ A‎‎ Significant‎‎ Relationship.

Conclusion: There‎‎ Was‎‎ An‎‎ Increase‎‎ In‎‎ Collagen‎‎ Density‎‎ In‎‎ Tracheal‎‎ Defects‎‎ Reconstructed‎‎ With‎‎ An‎‎ External‎‎ Oblique‎‎ Muscle‎‎ Aponeurosis‎‎ Patch‎‎ Combined‎‎ With‎‎ Dry‎‎ Amniotic‎‎ Membrane‎‎ (Dam)‎‎ Compared‎‎ To‎‎ Tracheal‎‎ Defects‎‎ Reconstructed‎‎ With‎‎ An‎‎ External‎‎ Oblique‎‎ Muscle‎‎ Aponeurosis‎‎ Patch‎‎ Alone.

Keywords: primary‎‎ tracheal‎‎ repair,‎‎ Dry‎‎ Amniotic‎‎ Membrane‎‎ (DAM),‎‎ collagen‎‎ density.

How to cite this article: Santoso AA, Wibowo MD, Susilo DH, Comparative‎‎ Study‎‎ of‎‎ Collagen‎‎ Density‎‎ in‎‎ Reconstruction‎‎ of‎‎ Trachea‎‎ Defects‎‎ with‎‎ Aponeurosis‎‎ Patch‎‎ of‎‎ External‎‎ Oblicus‎‎ Muscle‎‎ and‎‎ Dry‎‎ Amnion‎‎ Membrane‎‎ (A‎‎ Study‎‎ with‎‎ New‎‎ Zealand‎‎ Rabbits)‎‎. Int J Drug Deliv Technol. 2026;16(2s): 279-286; DOI: 10.25258/ijddt.16.279-286