Background: DFU is a high complication that impacts millions of human beings around the world. DFUs are often complicated by bacterial infections and the increasing incidence of antibiotic resistance is a major problem to treatment. This experiment sought to determine the bacterial pathogens present in DFUs in addition to measuring their resistance to antibiotics as well as seeing the viability of endophytic mangrove plant fungi as an alternative source of antibacterial agent.
Methods: 233 participants with DFUs were used in the study. The severity of ulcer was measured using Wagner classification system. Swab samples were taken and the bacteria identified the technique.
Results: The research found out that the prevalence of DFUs is high with Grade II ulcers being dominant. Isolated bacterial species were mostly polymicrobial, Staphylococcus aureus and Escherichia coli. Worryingly, these were highly resistant bacteria to most of the common antibiotics including Penicillin, Tetracycline and Erythromycin. This observation highlights the increased worry of antibiotic resistance in the infections associated with DFU. Although the antioxidant property of endophytic fungi growing in mangrove deserves further research, the antimicrobial factor of such fungi against any DFU pathogen has not been investigated in this case.
Conclusion: More studies are also needed to find alternative treatment methods, like endophytic fungi, and to enforce more rigorous policies of antibiotic stewardship in order to address this growing issue and enhance patient outcomes.
Keywords: Diabetic, Foot Ulcers, Antibiotic Resistance, Endophytic Fungi.
How to cite this article: Jeyakani J, SathyaPrabha G., Diabetic Foot Ulcers With Antibiotic Resistance And Anti-Bacterial Potential Of Compounds Isolated On Endophytic Fungi. Int J Drug Deliv Technol. 2026;16(2s): 56-62; DOI: 10.25258/ijddt.16.56-62