Recently, in the field of biotechnology, the integration of diverse chemical elements like nickel, copper, molybdenum, Selenium (Se), and so on has increased. Out of these elements, Se is one of the vital chemical elements used in biotechnology for its therapeutic and clinical treatments and Antioxidant (AO), Anticancer (AC), and Antimicrobial (AM) roles. Recent advances in biotechnology have led to the development of synthesized nano-Se to advance the therapeutic range of Se. The synthesized Nano Selenium (NS) offers improved bioavailability, higher biological activity, etc., with reduced toxicity levels. The characteristics like enhanced bioavailability, increased biological efficacy, and minimized toxicity are collectively attributed to a process known as Bio-Fabrication (BF), where biological systems or processes are utilized to design and develop nanomaterials with superior functional properties. The Biofabricated Se Nanoparticles (SeNPs) have shown improved results among the various synthesized nano-Se. The BF method uses plants, fungi, or other biological sources to create the SeNPs for enhanced therapeutic potential. It aims to highlight their potential as safer and more effective alternatives to conventional Se forms, especially in AM, AC, and AO therapies. Moreover, the review identifies existing gaps in current research and emphasizes the importance of overcoming challenges, such as source dependency, environmental factors, and regulatory barriers.
Keywords: Selenium Nanoparticles, Bio-fabrication, Green Synthesis, Anti-microbial, Anticancer, Antioxidant, nano selenium, and elemental selenium.
How to cite this article: Samanchi S, P J, P.V R, Ambika H, Ramya Y, Bramarambica K, Bio Fabricated Selenium Nanoparticles And Their Therapeutic Potential: Bridging The Gap Between Elemental Selenium And Bio-Fabricated Nano Selenium. Int J Drug Deliv Technol. 2026;16(2s): 408-419; DOI: 10.25258/ijddt.16.408-419