Objectives: Garcinia lanceifolia Roxb. Var. Oxyphylla (Clusiaceae), an important ethnomedicinal plant, widely used as medicine for jaundice, diarrhea, gastrointestinal and urinary problems. The aim of the study was to evaluate the acute oral toxicity and safety profile of the hydroalcoholic fruit extract of Garcinia lanceifolia Roxb. in Wistar rats.
Methods: Garcinia lanceifolia fruit extract (GLE) was administered orally to rats in graded doses up to 2000 mg/kg body weight. The animals were observed for 14 days to assess clinical signs of toxicity, behavioral changes, morbidity, and mortality. Body weight, food intake, and water consumption were recorded throughout the study. At the end of the experimental period, hematological and biochemical parameters were analyzed, and vital organs were examined histopathologically to assess any systemic toxicity.
Results: No mortality or significant behavioral abnormalities were observed at any of the tested doses. Body weight gain, food consumption, and water intake were comparable to the control group. Hematological values remained within normal physiological ranges, indicating no adverse effects on blood components. Biochemical analysis showed only significant fluctuations in ALT and cholesterol levels at the highest dose (2000 mg/kg), but all the biochemical parameters remained within reference limits. Histopathological evaluation of the liver, kidney, and spleen revealed preserved organ architecture with only mild, non-specific changes.
Conclusion: The hydroalcoholic fruit extract of Garcinia lanceifolia demonstrated no significant acute toxicity in rats up to the dose of 2000 mg/kg. The findings indicate a wide margin of safety and support the safe oral use of the fruit extract, providing a basis for further pharmacological studies.
Keywords: Garcinia lanceifolia, acute toxicity, histopathology
How to cite this article: Kumar J, Sharma N, Kalpana, Katiyar P, Singh AK, Kala C, Kar A, Gupta PC, Acute Toxicity Assessment Of Hydroalcoholic Fruit Extract Of Garcinia Lanceifolia Roxb. In Wistar Rats. Int J Drug Deliv Technol. 2026;16(2s): 673-679; DOI: 10.25258/ijddt.16.673-679