International Journal of Drug Delivery Technology
Volume 16, Issue 2s

Exploring The Role Of Vitamin D Receptor And 25(Oh) Vitamin D In The Pathophysiology Of Hypothyroidism

Pundalik Rama Naik1, Swapnali Ravikiran2, Divija D A3, Ravichandra V4*, Prathibha K N5

1Tutor, Department of Biochemistry, Kodagu Institute of Medical Sciences, Madikeri, & PhD Scholar, at KS Hegde Medical Academy, NITTE (Deemed to be University), Karnataka, India.
2Associate Professor, Department of Biochemistry, Kodagu Institute of Medical Sciences, Madikeri, Karnataka, India.
3Assistant Professor, Department of Biochemistry, Kodagu Institute of Medical Sciences, Madikeri, Karnataka, India.
4*Professor, Department of Pharmacology, KS Hegde Medical Academy, NITTE (Deemed to be University), Karnataka, India.
5Tutor, Department of Biochemistry, Kodagu Institute of Medical Sciences, Madikeri, Karnataka, India.

ABSTRACT

Background: Thyroid hormone disorders are among the most prevalent diseases, significantly impacting public health in India and worldwide. Vitamin D has been associated with modulating thyroid neoplastic and autoimmune diseases, with the vitamin D receptor (VDR) acting as the primary receptor for vitamin D3.

Aim: This study aims to investigate the role of the Vitamin D receptor (VDR) and 25-hydroxyvitamin D (25(OH)D) levels in the pathophysiology of hypothyroidism by exploring their association in a South Indian population through a case-control design.

Methods: An observational study was conducted using a cross-sectional design involving 216 participants (108 with thyroid abnormalities and 108 healthy controls), aged 18-70, who were matched for age and sex. Participants with a history of thyroidectomy, pregnant women, and individuals under 18 years were excluded. Blood samples were collected from all participants for necessary investigations. Thyroid profiles, thyroid antibodies, and Vitamin D levels were assessed using a fully automated chemiluminescent hormone analyzer, and VDR levels were measured using a commercially available human ELISA kit. All biochemical parameters were analyzed using a fully automated biochemistry analyzer. A p-value of <0.05 was considered statistically significant.

Results: The VDR levels among cases and controls were 0.72 ± 0.30 and 2.26 ± 0.97, and 25(OH) D3 levels were 17.04 ± 6.03 & 22.09 ± 9.75, respectively. A statistically significant difference in VDR and 25(OH) D3 levels was found between the case and control groups (p < 0.05).

Conclusions: Our findings indicate that serum VDR levels are significantly lower in patients with thyroid abnormalities than in healthy controls, suggesting that VDR may serve as a diagnostic marker for thyroid dysfunction.

Keywords: VDR, Vitamin D Receptor; ELISA, enzyme-linked immunosorbent assay; 1,25(OH) D3, 1,25-dihydroxy vitamin D3.

How to cite this article: Naik PR, Ravikiran S, D A D, V R, K N P, Exploring The Role Of Vitamin D Receptor And 25(Oh) Vitamin D In The Pathophysiology Of Hypothyroidism. Int J Drug Deliv Technol. 2026;16(2s): 680-687; DOI: 10.25258/ijddt.16.680-687