Dengue is caused by four distinct serotypes of the dengue virus 1-4 (DENV-1-4), which are the Flaviviridae family and genus Flavivirus members. Finding severity indicators is challenging due to the wide range of reactions to DENV infection among individuals. Understanding how each serotype correlates with disease severity is critical for effective surveillance and targeted intervention strategies. The main aim of the study was to evaluate the association between DENV serotypes and severity of dengue illness using a systematic review and meta-analysis of global studies from 2010 to 2022. We systematically searched PubMed, Google Scholar, Science Direct, and Springer for studies reporting laboratory-confirmed dengue infections stratified by serotype and clinical severity. Included studies were assessed using the Newcastle-Ottawa Scale. Meta-analysis was conducted using a random-effects model, and heterogeneity was assessed using I² statistics. DENV-2 showed the highest proportion of association with severe dengue cases (64.52%) compared to DENV-1, DENV-3, and DENV-4. Subgroup estimates were analyzed, highlighting that DENV-2 has a higher association with severe cases of dengue fever compared to other serotypes. The dengue burden is rising worldwide, even though its prevalence varies remarkably. These findings suggest that DENV-2 may pose a higher risk for severe dengue, which can guide targeted public health interventions.
Keywords: Dengue Virus; Meta-analysis; Flavivirus serotypes, DENV-2
How to cite this article: Deepak TS, N C, Jain A, N Ramya, Khanum U, Srinivasa C, D Chandan, Shreevatsa KSB, Patil SS, Shivamallu C, Gopinath SM, Specific Severity Patterns In Dengue Virus Infection: A Systematic Review And Meta-Analysis. Int J Drug Deliv Technol. 2026;16(2s): 456-464; DOI: 10.25258/ijddt.16.456-464