1,3Department of Pharmaceutical Chemistry, University Institute of Pharma Sciences, Chandigarh University, Mohali-140413, Punjab, India. ORCID: https://orcid.org/0009-0003-1045-6714
2*University Institute of Pharma Sciences and Research, Chandigarh University, Mohali-140413, Punjab, India. Email: kundanresearch1381@gmail.com. ORCID: https://orcid.org/0000-0002-4543-1803
3Email: yashpal.singh@cumail.in
Amaranthus hybridus Linn. (Family: Amaranthaceae), commonly referred as green amaranth, is a cosmopolitan annual herb indigenous to tropical and subtropical regions. Historically utilized as both a nutritional staple and a traditional therapeutic agent, Amaranthus hybridus possesses a dense profile of bioactive phytoconstituents. Key secondary metabolites include flavonoids (notably quercetin and rutin), phenolic acids (caffeic and ferulic acids), and the alkaloid amaranthine (a betacyanin). Furthermore, the species is a significant source of essential micronutrients, including iron, calcium, and vitamins A and C. Recent preclinical investigations have substantiated its antioxidant, anti-inflammatory, antidiabetic, and antimicrobial properties. Notably, preliminary clinical data in cohorts with Type 2 Diabetes Mellitus indicate significant reductions in glycated hemoglobin (HbA1c) and a favorable modulation of lipid profiles. Beyond its primary role in mitigating micronutrient deficiencies, Amaranthus hybridus demonstrates versatility in food science-specifically as a substrate for gluten-free flour-and shows promise in the development of nutraceuticals and cosmeceuticals. This review synthesizes current knowledge on its role in addressing malnutrition and chronic metabolic disorders, while underscoring the imperative for extract standardization and large-scale clinical validation.
Keywords: Amaranthus hybridus, phytochemical diversity, antioxidant potential, anti-inflammatory activity, antidiabetic potential.
How to cite this article: Kant K, Bora KS, Singh YP. Phytochemical and Therapeutic Potential of Amaranthus hybridus Linn: A Systematic Review. Int J Drug Deliv Technol. 2026;16(3): 86-94. DOI: 10.25258/ijddt.16.3.12
Source of support: Nil.
Conflict of interest: None