1Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Maduravoyal, Chennai 600095, Tamil Nadu, India
2*Professor and Head, Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Maduravoyal, Chennai 600095, Tamil Nadu, India. Email: drjaideep.perio@madch.edu.in
3#Associate Professor, School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai-600048, Tamil Nadu, India. Email: panduashokkumar@gmail.com
4Sri Ramachandra Medical College and Research Institute, Porur, Chennai, India
The objective of this research is to examine the anticancer efficacy of Adhatoda vasica extract against oral cancer utilizing KB human oral cancer cell models. Oral cancer continues to be a significant health burden, necessitating the urgent discovery of innovative therapeutic compounds derived from plants. Adhatoda vasica, a medicinal plant, was evaluated for its cytotoxic effects on KB cells. Various quantities of the plant extract were administered to the cells, and cell viability was assessed using established assays to evaluate its efficacy in inhibiting the proliferation of malignant cells. The results demonstrated a dose-dependent reduction in cell viability, suggesting that the extract can induce cytotoxicity in oral cancer cells. The comprehensive research revealed that the cells exhibited morphological alterations typical of apoptosis, suggesting that Adhatoda vasica may induce programmed cell death pathways. Consequently, these findings suggest that the extract may serve as a complementary or alternative therapeutic agent in the treatment of oral cancer. Adathoda vasica extract regulates the expressions of p53, Bax, Bcl2, and caspase-3. The study advocates for additional research on the extraction of active compounds, clarification of the molecular pathways involved, and in vivo validation of the extract's effectiveness. This research contributes to the body of plant-based therapies in oncology and advocates for further investigation of traditional medicinal herbs for cancer treatment.
Keywords: Oral cancer, Adhatoda vasica, p53, Apoptosis, Bcl2, Bax.
How to cite this article: Kamal HF, Mahendra J, Pandurangan AK, Bedi M. Ethanolic Extract of Adhatoda Vasica Induces Apoptosis in KB Human Oral Cancer Cell Line Model. Int J Drug Deliv Technol. 2026;16(3): 148-156. DOI: 10.25258/ijddt.16.3.19
Source of support: Nil.
Conflict of interest: None