1*Assistant Professor, Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai – 602105, Tamil Nadu, India. ORCID - 0000-0002-7512-0555. Corresponding Author. Contact number: +91 – 8310946797, Email: snsrinivasan93@gmail.com
2Post Graduate, Department of General Medicine, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai – 602105, Tamil Nadu, India. ORCID - 0009-0004-8798-3309
3Senior Resident, Department of Pharmacology, Saveetha Institute of Medical Sciences and Technology, Saveetha University, Chennai – 602105, Tamil Nadu, India. ORCID - 0009-0008-4586-4554
4Assistant Professor, Division of Allied Health Sciences, School of Health Sciences, The Apollo University, Murukambattu, Chittoor, Andhra Pradesh - 517127. ORCID - 0009-0000-8835-7976
5Associate Professor, Department of Pharmaceutical Chemistry, Apollo Institute of Pharmaceutical Sciences, The Apollo University, The Apollo Knowledge City, Saketa, Chittoor, Andhra Pradesh - 517127. ORCID - 0000-0002-2287-2286
6Associate Professor, Department of Pharmaceutical Chemistry, Apollo Institute of Pharmaceutical Sciences, The Apollo University, The Apollo Knowledge City, Saketa, Chittoor, Andhra Pradesh - 517127. ORCID - 0000-0003-0298-8705
Received: 12th Dec, 2025; Revised: 12th Feb 2026; Accepted: 13th Feb, 2026; Available Online: 10th March, 2026
Running Title: "Adiponectin Upregulation in Insulin Resistance Therapy"
The phenomenon of insulin resistance is an important pathopathology that contributes to the incidence of diabetes mellitus type 2, obesity, and metabolic syndrome, and is an important health issue globally. The adipokine Adiponectin, which is secreted mostly by adipose tissue, former highlighted as a main controller of metabolic homeostasis through its insulin-sensitizing, anti-inflammatory and anti-atherogenic effects. A reduction in the levels of adiponectin is directly linked with the enlargement of insulin resistance and previous metabolic complications. This research paper is based on the therapeutic purpose of the adiponectin upregulation in ornamental insulin compassion and metabolism. It explains about the molecular mechanisms involved especially activation of AMP-activated protein kinase (AMPK) as well as peroxisome proliferator-activated receptor-alpha (PPAR-alpha) that aid in amplified glucose uptake, elevated fatty acid oxidation as well as reduced hepatic glucose output. The paper also assesses some pharmacological solutions, which are synthetic drugs e.g. thiazolidinediones, and natural compounds and new adiponectin receptor agonists which increase adiponectin expression or activity. Also, the up-to-date issues, clinical evidence, and perspectives of adiponectin-targeted therapy are critically reviewed. Altogether, the adiponectin up-regulation is an innovative and promising pharmacological approach to the successful treatment of the insulin resistance and the disorders that are connected by it.
Keywords: Adiponectin; Insulin resistance; AMPK; PPAR-α; Type 2 diabetes mellitus; Pharmacotherapy
How to cite this article: Srinivasa B, Devaraneni A, Francis Rajadass J, Reganti A, Sreerama R, Grandhe N. Therapeutic Role of Adiponectin Upregulation in the Management of Insulin Resistance: Pharmacological Perspectives. Int J Drug Deliv Technol. 2026;16(3): 554-562. DOI: 10.25258/ijddt.16.3.62
Source of support: Nil.
Conflict of interest: None