1Research Scholar, Faculty of Pharmaceutical Sciences, Madhav University, Abu Road, Pindwara, Sirohi, Rajasthan, India. Corresponding Author. Email: babshettyrohit@gmail.com
2Professor, Faculty of Pharmaceutical Sciences, Madhav University, Abu Road, Pindwara, Sirohi, Rajasthan, India
Received: 12th Dec, 2025; Revised: 12th Feb 2026; Accepted: 13th Feb, 2026; Available Online: 10th March, 2026
In this study, aim was to formulate Furosemide solid dispersions to modify the drug's solubility and enhance therapeutic effect. Furosemide, loop diuretic, suffers from poor aqueous solubility, which limits its bioavailability. Solid dispersions were prepared using Eudragit L100 as carriers in different drug-to-carrier ratios through solvent evaporation and physical mixing techniques. These dispersions were assessed for bulk density, particle size, tapped density, angle of repose, also drug release profile. The findings indicated a notable improvement in the dissolution rate and solubility of Furosemide in an optimized formulation. The yields of solid dispersions were found to range 67.9%–95.4%, being the drug content of SDF2, the highest (97.63%). Solubility increase was also significant SDF2 showing 0.1100 mg/mL against 0.0697 mg/mL for pure Furosemide. Flow properties were within limits, and SDF2 showed best flow (angle of repose: 22.23°). SDF2 also exhibited the highest drug release (94.95% ± 2.07%) and micro particle size (173–186 µm). As a whole, SDF2 (drug: carrier 1:2) was chosen as the optimal formulation.
Keywords: Furosemide, Solid dispersions, Solubility enhancement, Eudragit polymers
How to cite this article: Basavraj BR, Kumar M. Formulation and Evaluation of Furosemide Solid Dispersions for Solubility and Bioavailability Enhancement. Int J Drug Deliv Technol. 2026;16(3): 631-636. DOI: 10.25258/ijddt.16.3.69
Source of support: Nil.
Conflict of interest: None